{"id":"W3084467698","doi":"10.20411/pai.v5i1.348","title":"Pharmacological Inhibition of PPAR<sub>y</sub> Boosts HIV Reactivation and Th17 Effector Functions, while Preventing Progeny Virion Release and <i>de novo</i> Infection","year":2020,"lang":"en","type":"article","venue":"Pathogens and Immunity","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Clinical Research Institute; Caprion (Canada); Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Provirus; Tetherin; Biology; Downregulation and upregulation; C-C chemokine receptor type 6; RAR-related orphan receptor gamma; Effector; Viral replication; Transcriptional regulation; Transcription factor; Virology; Cell biology; Cancer research; Molecular biology; Receptor; Chemokine receptor; Virus; Chemokine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006924792,0.0003074701,0.0004118579,0.000148127,0.0007030534,0.00004683285,0.00006560756,0.0003161017,0.000107461],"category_scores_gemma":[0.0004227193,0.000271908,0.0001049765,0.000260603,0.0003018,0.0002811159,0.0002174876,0.000455045,0.00008167444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000927328,"about_ca_system_score_gemma":0.00008770436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002823513,"about_ca_topic_score_gemma":0.000043234,"domain_scores_codex":[0.9975511,0.001003801,0.0004200963,0.0004678702,0.0001024121,0.0004547192],"domain_scores_gemma":[0.998936,0.0003122053,0.00024429,0.0002053146,0.0001498764,0.0001523379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008209449,0.000547098,0.01021709,0.0001693277,0.0002635049,0.00001813053,0.0004513604,0.00000321318,0.966327,0.00005430811,0.000797321,0.02033069],"study_design_scores_gemma":[0.00482795,0.002110261,0.3084361,0.0001629465,0.000408741,0.0002068697,0.00007045652,0.0001788077,0.668522,0.00006407315,0.01460045,0.0004114108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925971,0.004934611,0.0002867821,0.000259882,0.0001104152,0.001012212,0.0004364683,0.00009592826,0.0002665982],"genre_scores_gemma":[0.9947707,0.00368456,0.00008100397,0.00006577442,0.00006685432,0.0001520812,0.001071167,0.00002445534,0.00008340853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.298219,"threshold_uncertainty_score":0.9999733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0184301930519848,"score_gpt":0.2475454929846163,"score_spread":0.2291152999326315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}