{"id":"W3084467698","doi":"10.20411/pai.v5i1.348","title":"Pharmacological Inhibition of PPAR<sub>y</sub> Boosts HIV Reactivation and Th17 Effector Functions, while Preventing Progeny Virion Release and <i>de novo</i> Infection","year":2020,"lang":"en","type":"article","venue":"Pathogens and Immunity","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Clinical Research Institute; Caprion (Canada); Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Provirus; Tetherin; Biology; Downregulation and upregulation; C-C chemokine receptor type 6; RAR-related orphan receptor gamma; Effector; Viral replication; Transcriptional regulation; Transcription factor; Virology; Cell biology; Cancer research; Molecular biology; Receptor; Chemokine receptor; Virus; Chemokine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382678,0.0003773668,0.0004539373,0.0002263886,0.0001542889,0.000314527,0.0002543273,0.0003205442,0.002943421],"category_scores_gemma":[0.00008321045,0.0001704853,0.0004089767,0.000215813,0.0003744942,0.000170967,0.0001937583,0.001313125,0.0008739829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002122145,"about_ca_system_score_gemma":0.0005278853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005869748,"about_ca_topic_score_gemma":0.001308179,"domain_scores_codex":[0.9998636,0.00002496202,0.0000120725,0.00002350562,0.00002449341,0.00005142445],"domain_scores_gemma":[0.9999508,0.00000876936,0.00001270934,0.000005382537,0.00000406308,0.00001826664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003098895,0.0005287211,0.0003157433,0.0003008588,0.00004375669,0.00008620876,0.00003309852,0.0003711509,0.9819322,0.000451168,0.000730888,0.01210727],"study_design_scores_gemma":[0.0004861671,0.004577245,0.003539469,0.00003115779,0.0001109648,0.0003560823,0.0000931242,0.001437177,0.9782648,0.0002456748,0.01083949,0.00001856444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824241,0.003030372,0.004452833,0.0006986418,0.0002331665,0.0001270323,0.001564898,0.0004267052,0.007042349],"genre_scores_gemma":[0.9815665,0.003150667,0.005613899,0.0004739938,0.00007751866,0.0002713582,0.001637283,0.00007248793,0.007136323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002943421,"threshold_uncertainty_score":0.009846747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0184301930519848,"score_gpt":0.2475454929846163,"score_spread":0.2291152999326315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}