{"id":"W3084556360","doi":"10.1073/pnas.2007224117","title":"Early programming of CD8 <sup>+</sup> T cell response by the orphan nuclear receptor NR4A3","year":2020,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Cytotoxic T cell; CD8; Effector; Biology; Transcription factor; Chromatin; Cell biology; T cell; Immune system; Memory T cell; Immunology; Genetics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001256569,0.000195511,0.0001739842,0.0001101758,0.0001236387,0.0002327068,0.0001829382,0.0001930493,0.003086722],"category_scores_gemma":[0.0001549308,0.00009418827,0.0002475515,0.00005067105,0.0003073938,0.0001915988,0.0002170135,0.0006223563,0.0007616368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003201957,"about_ca_system_score_gemma":0.0002622948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000752825,"about_ca_topic_score_gemma":0.001474932,"domain_scores_codex":[0.9998903,0.00001916406,0.00001001497,0.00002184331,0.00002145038,0.00003714063],"domain_scores_gemma":[0.9999174,0.00001273861,0.00002372734,0.00001210781,0.00001126597,0.00002273085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002449318,0.000008963353,0.0003162362,0.00002364466,0.000002432456,0.00006534952,0.00001202666,0.00005679869,0.9974911,0.0002374636,0.0000714624,0.001469539],"study_design_scores_gemma":[0.00004432566,0.0003274454,0.01198956,0.00002653863,0.00001725966,0.0005152058,0.000138574,0.001142812,0.9794189,0.0005495212,0.005821072,0.000008736451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801194,0.003551167,0.007980214,0.0005586604,0.0001202368,0.00003432604,0.0008489561,0.0002771133,0.006509781],"genre_scores_gemma":[0.9929443,0.0007391343,0.002448524,0.0001142194,0.000009869053,0.00002228535,0.0002915165,0.00003937143,0.003390909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003086722,"threshold_uncertainty_score":0.01032609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04442172944780634,"score_gpt":0.2736483949883234,"score_spread":0.229226665540517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}