{"id":"W3084705282","doi":"10.1021/jacs.0c06820","title":"Genetically Encoded Quinone Methides Enabling Rapid, Site-Specific, and Photocontrolled Protein Modification with Amine Reagents","year":2020,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Office of Science; National Institutes of Health; University of Toronto; Canada Excellence Research Chairs, Government of Canada; National Institute of General Medical Sciences; National Institute of Mental Health; Canadian Institute for Advanced Research","keywords":"Chemistry; Reagent; Amine gas treating; Chemical modification; Combinatorial chemistry; Quinone; Small molecule; Molecule; Electron paramagnetic resonance; Surface modification; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001579281,0.0003043593,0.0001247542,0.00009909649,0.00008166794,0.000143317,0.00022172,0.0002538242,0.0005842408],"category_scores_gemma":[0.0001595239,0.0001321286,0.0001187085,0.00007433927,0.0002224469,0.0002349095,0.0001877457,0.0003121176,0.0001829525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001741568,"about_ca_system_score_gemma":0.0001066342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003676865,"about_ca_topic_score_gemma":0.00056476,"domain_scores_codex":[0.9999074,0.00001507364,0.000005399965,0.00002762964,0.0000282068,0.00001628283],"domain_scores_gemma":[0.9998673,0.00002512917,0.00005821532,0.00001627843,0.00001331697,0.00001974583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001086738,0.000003260316,0.00003316701,0.000009670939,8.810223e-7,0.00001456525,0.00000530137,0.00004506737,0.9991837,0.0000848793,0.000008038981,0.0006006813],"study_design_scores_gemma":[0.000002912354,0.00006130816,0.0004014691,8.263214e-7,0.000002290022,0.00007072757,0.00000235941,0.0003670061,0.9982381,0.00001845496,0.0008318618,0.000002820275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9595112,0.0006618428,0.03815818,0.00007912377,0.00002508942,0.00004457054,0.0001246895,0.0002098144,0.001185629],"genre_scores_gemma":[0.9825026,0.0003775465,0.01503722,0.00003124059,0.000008368043,0.00002912965,0.0000987837,0.0000325469,0.001882621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005842408,"threshold_uncertainty_score":0.001954496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02410469510882899,"score_gpt":0.2538228333966477,"score_spread":0.2297181382878188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}