{"id":"W3084780453","doi":"10.1126/sciadv.abc0367","title":"LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"H2020 Marie Skłodowska-Curie Actions; Faculty of Medicine and Health, University of Sydney; Horizon 2020; Helse Sør-Øst RHF; Universitetet i Oslo; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Genomics; Ontario Ministry of Research, Innovation and Science; Norwegian Sequencing Centre; Helse Midt-Norge; Novartis Pharma; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Novo Nordisk Fonden; Norges Forskningsråd; Kreftforeningen; Pfizer","keywords":"Intestinal epithelium; Epithelium; Gene; Biology; Genetics; Cell biology; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001876696,0.0001119611,0.0001221483,0.00004128719,0.0001069887,0.00002987471,0.00031367,0.00004616735,0.000004324864],"category_scores_gemma":[0.0005105129,0.00008771748,0.00002909805,0.0005270445,0.000509865,0.00002834373,0.0001045783,0.00009360355,0.00002047668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001449637,"about_ca_system_score_gemma":0.0002636958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001953565,"about_ca_topic_score_gemma":0.00003800975,"domain_scores_codex":[0.9987308,0.00003709259,0.0001949041,0.0005375689,0.0001898313,0.0003098049],"domain_scores_gemma":[0.9994057,0.00001129038,0.00009167063,0.0001664187,0.0001779468,0.0001469946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002344334,0.0001422481,0.03059192,0.0001096212,0.00001151106,0.00005181881,0.001584214,0.001159498,0.8647112,0.0004320276,0.000195897,0.1007757],"study_design_scores_gemma":[0.0005937302,0.001725242,0.007399159,0.0001214534,0.000005503903,0.00004427316,0.001320754,0.0003599589,0.9561157,0.000218828,0.03176473,0.0003306254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891267,0.004050944,0.0008649207,0.001087381,0.0002156027,0.0005075804,0.00001082726,0.00004602354,0.004089999],"genre_scores_gemma":[0.9945756,0.0002432299,0.004472489,0.0004205624,0.0001112718,0.00005271841,0.00001017997,0.000006918047,0.0001070397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.100445,"threshold_uncertainty_score":0.3577015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01279083080167498,"score_gpt":0.3191094594902134,"score_spread":0.3063186286885384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}