{"id":"W3084832835","doi":"10.1101/2020.09.14.293290","title":"The DNA Damage-Sensing NER Repair Factor XPC-RAD23B Does Not Recognize Bulky DNA Lesions with a Missing Nucleotide Opposite the Lesion","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; York University; National Institutes of Health; National Science Foundation","keywords":"DNA; Chemistry; DNA damage; Oligonucleotide; Stereochemistry; Nucleotide excision repair; Nucleotide; Base pair; Nucleobase; Lesion; Biophysics; Biochemistry; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001870219,0.0004331599,0.000408435,0.0002245039,0.0001716486,0.0004268129,0.0004134416,0.0004779167,0.001640607],"category_scores_gemma":[0.00036709,0.0003441393,0.0001898481,0.0001701001,0.000378628,0.0001837837,0.0003244065,0.0006119037,0.0009344678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003646726,"about_ca_system_score_gemma":0.0002174588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001058444,"about_ca_topic_score_gemma":0.0009771446,"domain_scores_codex":[0.9995401,0.00005030855,0.00003475323,0.0001368041,0.0001894604,0.00004863189],"domain_scores_gemma":[0.999585,0.00005975183,0.00008978448,0.0000896823,0.00006321436,0.0001125905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002502857,0.000008770499,0.00008860308,0.00000939139,0.000005178268,0.00001290494,0.000002361388,0.00003808064,0.9995726,0.00001835607,0.0000124152,0.0002062845],"study_design_scores_gemma":[0.00000531103,0.0001134731,0.002524971,0.000002590711,0.000007081985,0.000206832,0.000007823814,0.0005527182,0.9950101,0.00001991115,0.001543788,0.000005368415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930607,0.001077751,0.004609044,0.00006301318,0.00002540094,0.00001971262,0.0002511551,0.0001454781,0.0007476837],"genre_scores_gemma":[0.9948555,0.0002038599,0.002096923,0.00006028632,0.000004894822,0.00001828465,0.0008606768,0.0000713128,0.001828278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001640607,"threshold_uncertainty_score":0.005488396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01958158393386321,"score_gpt":0.226854381366437,"score_spread":0.2072727974325738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}