{"id":"W3084895703","doi":"10.2174/1874467213666200910091007","title":"The Effect of PAOPA, a Novel Allosteric Modulator of Dopamine D2 Receptors, on Signaling Proteins Following Sub-Chronic Administration in Rats","year":2020,"lang":"en","type":"article","venue":"Current Molecular Pharmacology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Allosteric regulation; Allosteric modulator; Dopamine; Striatum; Dopamine receptor D2; Beta adrenergic receptor kinase; Pharmacology; Nucleus accumbens; Receptor; Dopamine receptor; Neuroscience; Chemistry; Biology; G protein-coupled receptor; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003063098,0.0002860772,0.0004077172,0.0001175902,0.00007243869,0.00001961211,0.0005025275,0.00007406289,0.00003012436],"category_scores_gemma":[0.0002380652,0.0002369503,0.0002144796,0.0006002567,0.0001850073,0.00011084,0.00008372239,0.0004544627,0.00001363768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008466192,"about_ca_system_score_gemma":0.0001260231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000161649,"about_ca_topic_score_gemma":7.667956e-7,"domain_scores_codex":[0.9972314,0.000708253,0.0006390462,0.0005791468,0.000438476,0.0004036799],"domain_scores_gemma":[0.9989612,0.0003503752,0.0003194875,0.0002102446,0.000030454,0.0001283087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004592123,0.000179412,0.000725923,0.0001830731,0.00001108678,0.00004846709,0.0000761631,0.0007818235,0.9895834,0.00002180471,0.00001665431,0.007912949],"study_design_scores_gemma":[0.002062846,0.002399188,0.00009653781,0.0001067552,0.00006681632,0.000005800959,0.000002382715,0.001193095,0.9932846,0.000002222348,0.0006013744,0.0001783121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952411,0.0003192047,0.0008588182,0.0004456223,0.001144145,0.001928109,0.00001238492,0.00004380951,0.000006781066],"genre_scores_gemma":[0.9993337,0.00003828289,0.00002440013,0.0001904421,0.00007114255,0.0002963682,0.0000046964,0.00003896173,0.000001990894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007734637,"threshold_uncertainty_score":0.9662555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03227001048558524,"score_gpt":0.3277676099245852,"score_spread":0.2954975994389999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}