{"id":"W3085064254","doi":"10.7554/elife.58668","title":"Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of British Columbia; Vancouver Coastal Health","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Simons Foundation; Fondation pour la Recherche Médicale; National Institutes of Health; Agence Nationale de la Recherche","keywords":"Neurexin; Neuroligin; Synaptogenesis; Alternative splicing; Synapse; Biology; RNA splicing; Cell biology; Neuroscience; Neurotransmission; Genetics; Gene isoform; Gene; Receptor; Inhibitory postsynaptic potential; Postsynaptic potential","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000965968,0.0001599128,0.0001149609,0.000105917,0.0001137717,0.0002432041,0.0001050848,0.0001691404,0.0007138902],"category_scores_gemma":[0.00009121584,0.00007389112,0.0001560106,0.00007513356,0.0001893188,0.0001263103,0.0001629007,0.0002648561,0.0002689189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002612406,"about_ca_system_score_gemma":0.0001405447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007579247,"about_ca_topic_score_gemma":0.001368648,"domain_scores_codex":[0.9999193,0.000009776426,0.000005638963,0.00002389055,0.00002090694,0.00002061502],"domain_scores_gemma":[0.9999195,0.00001086332,0.00002997259,0.000006881293,0.00001237874,0.00002034428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006052516,0.000004327404,0.0006730366,0.000006350975,0.000002862519,0.00007700031,0.000008730834,0.00002487771,0.9982445,0.00009453873,0.00001333474,0.0007898292],"study_design_scores_gemma":[0.00001577315,0.0001381522,0.06177979,0.000006797547,0.00002257616,0.0006452369,0.00009277098,0.00124384,0.9337663,0.000376267,0.00190306,0.000009438126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974418,0.0004294869,0.00108609,0.00004083296,0.00000670277,0.000002942371,0.00008797674,0.00001771812,0.0008865872],"genre_scores_gemma":[0.9981179,0.000257895,0.0006105943,0.00002046167,0.000002530323,0.000002816551,0.0001077088,0.000009175745,0.0008710259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007579247,"threshold_uncertainty_score":0.002388179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07968847086569958,"score_gpt":0.3526119948025382,"score_spread":0.2729235239368386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}