{"id":"W3085068313","doi":"10.1084/jem.20200559","title":"A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans","year":2020,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"T. Von Zastrow Foundation; Austrian Science Fund; Österreichischen Akademie der Wissenschaften","keywords":"Glycosylation; Antibody; Biology; Immunology; Humoral immunity; Immune system; Unfolded protein response; Endoplasmic reticulum; Secretion; Immunity; Immunoglobulin G; Fucosylation; Molecular biology; Cell biology; Glycoprotein; Genetics; Endocrinology; Glycan","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002246007,0.0004474845,0.0002409415,0.0005131796,0.0001745332,0.000311379,0.000238229,0.0004879932,0.001078962],"category_scores_gemma":[0.0002123473,0.0001207753,0.0001460754,0.0001462245,0.0005064829,0.0002370447,0.0004723875,0.0002907939,0.0001286424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001995464,"about_ca_system_score_gemma":0.000151631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002146326,"about_ca_topic_score_gemma":0.000154614,"domain_scores_codex":[0.9998549,0.00003321516,0.0000146863,0.00005587412,0.0000248487,0.00001648475],"domain_scores_gemma":[0.9998894,0.00001906957,0.00004878073,0.00001198924,0.000005493713,0.00002535229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001608833,0.00009899658,0.01655254,0.0003604187,0.0001140146,0.0040739,0.0001823891,0.0002849526,0.9376779,0.003715368,0.0007551652,0.0345755],"study_design_scores_gemma":[0.0003915309,0.001806499,0.4869448,0.0003503998,0.0005663013,0.07412449,0.0005594382,0.003169015,0.3609499,0.006417307,0.06462773,0.00009263033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838641,0.009086835,0.003345702,0.0004672908,0.00004337491,0.00001903927,0.0004669019,0.0001860354,0.002520712],"genre_scores_gemma":[0.9942132,0.002504648,0.002103196,0.0001802271,0.0000189078,0.00001995032,0.0002861505,0.00001728906,0.000656414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001078962,"threshold_uncertainty_score":0.003609478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04658953606130244,"score_gpt":0.378903398013982,"score_spread":0.3323138619526795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}