{"id":"W3085117737","doi":"10.1016/j.jaad.2020.09.037","title":"Twice-weekly topical calcipotriene/betamethasone dipropionate foam as proactive management of plaque psoriasis increases time in remission and is well tolerated over 52 weeks (PSO-LONG trial)","year":2020,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; University of Toronto","funders":"Daiichi Sankyo Europe; Samsung; Sandoz; Janssen Pharmaceuticals; Sanofi Genzyme; Novartis; Merck Sharp and Dohme; Bausch Health; Allergan; Beiersdorf; Janssen Research and Development; Language Literacy and Culture, University of Maryland, Baltimore County; EMD Serono; Almirall; MorphoSys; Galderma; Bayer; Astellas Pharma; Daiichi-Sankyo; National Institute for Health and Care Research; LEO Pharma; UCB Pharma; Dermira; Galápagos; MedImmune; Janssen UK; Sanofi; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Ortho Dermatologics; Celgene; Johnson and Johnson; Les Laboratories Pierre Fabre; Regeneron Pharmaceuticals; Takeda Pharmaceutical Company; Amgen; Boehringer Ingelheim; Schering-Plough; AbbVie; Roche; Merck; GlaxoSmithKline; Incyte; Pfizer; Biogen; Asana Biosciences; Santen; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca","keywords":"Medicine; Betamethasone dipropionate; Randomized controlled trial; Psoriasis; Clinical endpoint; Internal medicine; Dermatology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008205758,0.000510016,0.0008395939,0.0002150146,0.000192356,0.0004644864,0.0003841055,0.0007258056,0.004003106],"category_scores_gemma":[0.0004668483,0.0002014858,0.0008415715,0.0001693886,0.0003113621,0.0003176323,0.0001521305,0.001117423,0.0004038542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002515554,"about_ca_system_score_gemma":0.0004523264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004213005,"about_ca_topic_score_gemma":0.001363014,"domain_scores_codex":[0.9997943,0.00008941966,0.00001382173,0.0000364988,0.00003334651,0.00003254119],"domain_scores_gemma":[0.9997248,0.00007836638,0.00007020136,0.00001878302,0.00002111441,0.00008679795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7121901,0.01433485,0.002823545,0.001970682,0.001322833,0.0001211892,0.0001002645,0.0005693394,0.02526031,0.0003149835,0.003656926,0.237335],"study_design_scores_gemma":[0.8371011,0.1478867,0.008877173,0.000136167,0.0005677504,0.0001491929,0.00003006327,0.0006428162,0.002302657,0.0001152944,0.002176392,0.00001480626],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756601,0.01584409,0.0006816849,0.0007461994,0.0004277542,0.001700214,0.0005624863,0.0001827413,0.004194627],"genre_scores_gemma":[0.989372,0.003789289,0.001281437,0.0008737685,0.0002660605,0.001008732,0.0005465354,0.0000121166,0.002850045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004003106,"threshold_uncertainty_score":0.01339173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01794440259014538,"score_gpt":0.2784574218106345,"score_spread":0.2605130192204891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}