{"id":"W3085154348","doi":"10.1101/2020.09.16.291930","title":"BRD4-mediated repression of p53 is a target for combination therapy in AML","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Beatson Institute for Cancer Research; Howat Foundation; CHILDREN with CANCER UK; Constellation Pharmaceuticals; Leuka; Cancer Research UK; Wellcome Trust","keywords":"Cancer research; Myeloid leukemia; Psychological repression; Repressor; BRD4; Mdm2; Activator (genetics); Suppressor; Apoptosis; Gene; Biology; Chemistry; Genetics; Transcription factor; Gene expression; Bromodomain","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000352841,0.0003013143,0.0003776426,0.0001370448,0.00004351352,0.00003529277,0.0003123139,0.0005611402,0.00002136734],"category_scores_gemma":[0.0004347632,0.0003175114,0.0001525104,0.0002320841,0.00006304575,0.000008633538,0.0002277368,0.0002526626,0.000004776542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004372052,"about_ca_system_score_gemma":0.0003353143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002320223,"about_ca_topic_score_gemma":8.743203e-7,"domain_scores_codex":[0.9981965,0.0001032075,0.0005171814,0.0007379286,0.0002044565,0.0002407687],"domain_scores_gemma":[0.9983643,0.00001994495,0.0004525855,0.0006775034,0.0003758724,0.00010974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001636637,0.000152442,0.002938024,0.0001563614,0.0000544345,0.000001582047,0.000009316985,0.00001316573,0.9943335,0.00009421648,0.002076235,0.000007070741],"study_design_scores_gemma":[0.001347368,0.0002790101,0.01153309,0.0001459059,0.00001014907,2.474728e-9,0.000001682415,0.000523127,0.9683437,0.00001095395,0.01747686,0.0003281132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924677,0.001321752,0.003114081,0.000726015,0.0004883254,0.001401273,0.0004148707,0.0000559728,0.000009995644],"genre_scores_gemma":[0.9949927,0.0006470381,0.003324955,0.0004281536,0.0002123373,0.0003026796,0.00001616344,0.00006782342,0.000008120932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02598975,"threshold_uncertainty_score":0.9999277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01579458160239211,"score_gpt":0.240213940894869,"score_spread":0.2244193592924769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}