{"id":"W3085154348","doi":"10.1101/2020.09.16.291930","title":"BRD4-mediated repression of p53 is a target for combination therapy in AML","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Beatson Institute for Cancer Research; Howat Foundation; CHILDREN with CANCER UK; Constellation Pharmaceuticals; Leuka; Cancer Research UK; Wellcome Trust","keywords":"Cancer research; Myeloid leukemia; Psychological repression; Repressor; BRD4; Mdm2; Activator (genetics); Suppressor; Apoptosis; Gene; Biology; Chemistry; Genetics; Transcription factor; Gene expression; Bromodomain","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003168889,0.0003511737,0.000483654,0.0004566213,0.000139891,0.0004727007,0.0002922266,0.0002207347,0.002307759],"category_scores_gemma":[0.00013176,0.0001629108,0.0002607091,0.0002479207,0.0002457846,0.0001753017,0.0003720772,0.0005635759,0.0006715171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004392649,"about_ca_system_score_gemma":0.0002097931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000166243,"about_ca_topic_score_gemma":0.0003210161,"domain_scores_codex":[0.9998259,0.00003165995,0.00001143975,0.00002967143,0.00007033761,0.00003100738],"domain_scores_gemma":[0.9999547,0.000007118624,0.00001171784,0.000008969258,0.000005410453,0.00001221075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009398101,0.0001751825,0.001427051,0.0002050825,0.00006166215,0.0002334621,0.00002331213,0.00185557,0.9543703,0.001114535,0.001295147,0.0382989],"study_design_scores_gemma":[0.0001758188,0.0009416233,0.003034585,0.00001792062,0.00007550665,0.00099498,0.00001469523,0.002855299,0.9636456,0.0004803197,0.02775231,0.00001136597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9390474,0.02574421,0.01572097,0.001392414,0.0002372329,0.0002128628,0.001105333,0.0004683175,0.01607132],"genre_scores_gemma":[0.9856485,0.004708884,0.004620844,0.00009698528,0.00005103041,0.00007266363,0.0005831434,0.00005440454,0.004163559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002307759,"threshold_uncertainty_score":0.007720292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01579458160239211,"score_gpt":0.240213940894869,"score_spread":0.2244193592924769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}