{"id":"W3085172023","doi":"10.1177/1203475420952422","title":"Human Leukocyte Antigen Gene Testing and Carbamazepine-Induced Toxic Epidermal Necrolysis: A Study of Pediatric Practice","year":2020,"lang":"en","type":"article","venue":"Journal of Cutaneous Medicine and Surgery","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Toxic epidermal necrolysis; Medicine; Carbamazepine; Pharmacogenomics; Human leukocyte antigen; Haplotype; Drug; Dermatology; Allele; Immunology; Psychiatry; Epilepsy; Pharmacology; Antigen; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009445447,0.0002453379,0.001294986,0.0005129045,0.0001323161,0.00001446287,0.00007199904,0.00009740244,0.000009110922],"category_scores_gemma":[0.007702742,0.0001889716,0.0001245071,0.0006773163,0.00006973988,0.000231295,0.00004759546,0.0006132676,0.000001131971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004468948,"about_ca_system_score_gemma":0.0003423544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001967721,"about_ca_topic_score_gemma":0.000005555785,"domain_scores_codex":[0.997245,0.0001997286,0.001322542,0.0002626548,0.000692234,0.000277861],"domain_scores_gemma":[0.9950946,0.002274556,0.001253747,0.0001887775,0.0006221479,0.0005661461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007285817,0.002134394,0.2677719,0.0009342175,0.00256591,0.05188968,0.01492826,0.0001026527,0.6064723,0.000006609008,0.002589324,0.04987613],"study_design_scores_gemma":[0.02167052,0.01866072,0.4803081,0.002475824,0.02501271,0.3324248,0.09766402,0.001444381,0.01006122,0.00007744134,0.008324194,0.001876034],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921104,0.001846952,0.00000984464,0.004771151,0.000194933,0.0002672038,0.000001103147,0.00002390632,0.00077452],"genre_scores_gemma":[0.9956334,0.0009834274,0.000305532,0.001114898,0.001905617,0.000001770172,0.000001296341,0.00003321669,0.00002079427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5964111,"threshold_uncertainty_score":0.9221458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09958933884606204,"score_gpt":0.3299240882863155,"score_spread":0.2303347494402535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}