{"id":"W3085469110","doi":"10.3390/bioengineering7030115","title":"Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing","year":2020,"lang":"en","type":"review","venue":"Bioengineering","topic":"3D Printing in Biomedical Research","field":"Engineering","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Tissue engineering; Biochemical engineering; Computer science; Preclinical testing; Animal testing; Animal model; Human cell; Biomedical engineering; Engineering; Biology; Bioinformatics; Cell culture; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001411892,0.0008725579,0.001260313,0.002652207,0.0001878171,0.001157491,0.0009469746,0.001321938,0.003993488],"category_scores_gemma":[0.0008486632,0.0002850901,0.0006550227,0.001802886,0.0008554665,0.001404716,0.0007253509,0.002358542,0.001913659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006604931,"about_ca_system_score_gemma":0.0008263139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006710939,"about_ca_topic_score_gemma":0.0009879495,"domain_scores_codex":[0.9995111,0.0001112296,0.00004926326,0.00005663136,0.0002402894,0.00003151036],"domain_scores_gemma":[0.9994009,0.0003235138,0.00007019629,0.00002708926,0.0001436825,0.00003467701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007660535,0.0001389818,0.0001329228,0.01807762,0.00006792666,0.0002376574,0.0001010456,0.0007516111,0.01350307,0.02092152,0.02413687,0.9218543],"study_design_scores_gemma":[0.0000132499,0.0001352713,0.0004141272,0.002987014,0.0000585939,0.001269739,0.00005878812,0.0001958799,0.00314106,0.003841936,0.9878566,0.00002768017],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001886791,0.9954857,0.001240482,0.0002641025,0.0002603464,0.00001338832,0.00002291742,0.00001616507,0.002508123],"genre_scores_gemma":[0.001738805,0.9950674,0.001147097,0.0003183346,0.000167856,0.00003039134,0.00006927642,0.000005542184,0.00145539],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003993488,"threshold_uncertainty_score":0.01335955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1292506735856806,"score_gpt":0.3728984618565176,"score_spread":0.2436477882708371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}