{"id":"W3085547988","doi":"10.1002/ijc.33292","title":"Causal relationships between body mass index, smoking and lung cancer: Univariable and multivariable Mendelian randomization","year":2020,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University Health Network; University of Toronto; BC Cancer Agency; Princess Margaret Cancer Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; China Scholarship Council; Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Institute for Health and Care Research; Nanjing Medical University; Université Laval; Cancer Prevention and Research Institute of Texas; Centre International de Recherche sur le Cancer; World Health Organization; U.S. Department of Health and Human Services; National Institutes of Health; Cancer Research UK; Foundation for the National Institutes of Health","keywords":"Mendelian randomization; Body mass index; Randomization; Medicine; Lung cancer; Oncology; Internal medicine; Cancer; Multivariable calculus; Randomized controlled trial; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003993052,0.00008885731,0.0001815873,0.00005327242,0.00006951341,0.00003164105,0.000117679,0.0001254262,0.00003672783],"category_scores_gemma":[0.000496602,0.00008223769,0.00003681283,0.00005629568,0.00003398161,0.000016478,0.00005433186,0.0001735024,1.491551e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005293079,"about_ca_system_score_gemma":0.000172277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001459156,"about_ca_topic_score_gemma":0.00002173747,"domain_scores_codex":[0.9991328,0.000114367,0.0003428824,0.0001443209,0.0001557405,0.0001098726],"domain_scores_gemma":[0.9991025,0.0000730398,0.0003451269,0.00004355168,0.0003099163,0.0001259216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002020181,0.000006276905,0.9699382,0.000007762997,0.0006697952,0.000001997403,0.0001058846,0.007198995,0.01821971,0.0001478071,0.002038307,0.001463312],"study_design_scores_gemma":[0.01828904,0.0003098007,0.8492621,0.0002352744,0.0008333249,0.00004390537,0.0004963297,0.04912438,0.009871818,0.002094189,0.06879129,0.0006486051],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8901836,0.006149862,0.09042341,0.01202849,0.000617607,0.0001524137,0.00009065565,0.00000629556,0.0003476283],"genre_scores_gemma":[0.9949641,0.002257336,0.001300417,0.000415609,0.0009350973,0.000006909823,0.00002522399,0.00001111088,0.00008424982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1206761,"threshold_uncertainty_score":0.3353556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01921140168966034,"score_gpt":0.3102159233951523,"score_spread":0.291004521705492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}