{"id":"W3085547988","doi":"10.1002/ijc.33292","title":"Causal relationships between body mass index, smoking and lung cancer: Univariable and multivariable Mendelian randomization","year":2020,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University Health Network; University of Toronto; BC Cancer Agency; Princess Margaret Cancer Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; China Scholarship Council; Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Institute for Health and Care Research; Nanjing Medical University; Université Laval; Cancer Prevention and Research Institute of Texas; Centre International de Recherche sur le Cancer; World Health Organization; U.S. Department of Health and Human Services; National Institutes of Health; Cancer Research UK; Foundation for the National Institutes of Health","keywords":"Mendelian randomization; Body mass index; Randomization; Medicine; Lung cancer; Oncology; Internal medicine; Cancer; Multivariable calculus; Randomized controlled trial; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02159503,0.0008213057,0.001086129,0.0009453893,0.0005391098,0.0008343708,0.001024145,0.0007410396,0.002385432],"category_scores_gemma":[0.04434013,0.0005189595,0.002501765,0.0009229088,0.000729843,0.0004199716,0.0006636723,0.0008747518,0.0001730839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004322976,"about_ca_system_score_gemma":0.0008751962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003711729,"about_ca_topic_score_gemma":0.001999364,"domain_scores_codex":[0.9678724,0.02679287,0.0009401014,0.002437831,0.001549853,0.0004068864],"domain_scores_gemma":[0.9695095,0.02387819,0.002701784,0.003002106,0.0007307629,0.0001776531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02665191,0.001323385,0.690101,0.001271233,0.03738775,0.004096538,0.001446556,0.03232655,0.03374735,0.03389764,0.004008655,0.1337414],"study_design_scores_gemma":[0.007105385,0.009196814,0.4107066,0.0003064561,0.03119595,0.006192592,0.0003661006,0.4448736,0.01909107,0.06112252,0.009454638,0.0003882627],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7493391,0.001040188,0.2458482,0.000460391,0.0001370515,0.0005513728,0.001009333,0.0007167006,0.0008976773],"genre_scores_gemma":[0.9341053,0.0001536395,0.06441958,0.0002170323,0.00003660527,0.0003613244,0.0003609719,0.0000600797,0.0002855334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02159503,"threshold_uncertainty_score":0.1142068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01921140168966034,"score_gpt":0.3102159233951523,"score_spread":0.291004521705492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}