{"id":"W3085550079","doi":"10.3389/fphar.2020.575540","title":"Pharmacogenetics in Psychiatry: An Update on Clinical Usability","year":2020,"lang":"en","type":"review","venue":"Frontiers in Pharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"","keywords":"Pharmacogenetics; Pharmacogenomics; Medicine; Psychiatry; Medical prescription; Genetic testing; Personalized medicine; Genotyping; Pharmacology; Bioinformatics; Genotype; Genetics; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002266795,0.0008020015,0.001788639,0.00277139,0.0002668068,0.001751394,0.001022031,0.001522205,0.008497439],"category_scores_gemma":[0.00360253,0.0003388418,0.001072607,0.002490893,0.000668898,0.00223385,0.001194138,0.002638801,0.003348209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009227198,"about_ca_system_score_gemma":0.002165578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001384558,"about_ca_topic_score_gemma":0.002886438,"domain_scores_codex":[0.9992865,0.000207053,0.0001378185,0.00009276184,0.0002309096,0.00004499945],"domain_scores_gemma":[0.9967001,0.002294587,0.0002036074,0.000077837,0.0005945959,0.0001292236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005238481,0.00003493256,0.000158042,0.01604444,0.00009830989,0.0001510059,0.00005760966,0.0001452089,0.0004905262,0.003480665,0.03822793,0.9410591],"study_design_scores_gemma":[0.00001904438,0.00006906493,0.0006552421,0.009811553,0.0001660539,0.0008774314,0.00005478476,0.00008400446,0.0001442262,0.002538999,0.985558,0.00002153846],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005354364,0.9971878,0.000190805,0.001136335,0.0004186101,0.000005469833,0.00003822161,0.00001126602,0.0009579929],"genre_scores_gemma":[0.0004249391,0.9974965,0.000316269,0.0007315012,0.000484456,0.000007938575,0.00005228578,0.00000358552,0.0004824633],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008497439,"threshold_uncertainty_score":0.02842677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2331278570605818,"score_gpt":0.552387905742148,"score_spread":0.3192600486815662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}