{"id":"W3085614571","doi":"10.1093/cid/ciaa1371","title":"DNA Methylation and Immune Cell Markers Demonstrate Evidence of Accelerated Aging in Patients with Chronic Hepatitis B Virus or Hepatitis C Virus, with or without Human Immunodeficienct Virus Co-infection","year":2020,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Gilead Sciences","keywords":"Medicine; Immunology; Immune system; Hepatitis B virus; Viral load; DNA methylation; Hepatitis C virus; Virus; Epigenetics; Hepatitis B; Virology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002479595,0.0001307617,0.000182488,0.0002821858,0.0001376025,0.0001631873,0.00007458296,0.0001778491,0.001269526],"category_scores_gemma":[0.001167035,0.00007635049,0.0001273307,0.0002653327,0.0001156701,0.0001475401,0.0001651426,0.0001812364,0.0001145467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009561101,"about_ca_system_score_gemma":0.0001385792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009334156,"about_ca_topic_score_gemma":0.001418579,"domain_scores_codex":[0.9999167,0.00002223545,0.000009351189,0.00002453427,0.00001256175,0.00001470318],"domain_scores_gemma":[0.9993402,0.0001853304,0.0003234455,0.00003179024,0.00003886196,0.00008029632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001663031,0.00001294937,0.9963141,0.000006754663,0.00001723257,0.0000278998,0.00004364086,0.00004651397,0.0009693481,0.00001114728,0.00002123432,0.002362836],"study_design_scores_gemma":[0.00000320045,0.00012403,0.9991437,0.00000230115,0.00001088001,0.0001927386,0.00004107302,0.0002157759,0.0001702985,0.00002270504,0.00007222158,0.000001102984],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999542,0.0001575867,0.00009436831,0.00001081723,0.000001331229,0.000001873696,0.00004565386,0.000001989825,0.0001443679],"genre_scores_gemma":[0.9997353,0.00004228617,0.00008734709,0.000005745922,0.000003029985,0.000002082111,0.00005218345,4.482812e-7,0.00007160719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001269526,"threshold_uncertainty_score":0.00424695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03496093121774289,"score_gpt":0.3340254975582737,"score_spread":0.2990645663405307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}