{"id":"W3085724501","doi":"10.1111/hae.14131","title":"Gene therapy to cure haemophilia: Is robust scientific inquiry the missing factor?","year":2020,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Hemophilia Society","funders":"","keywords":"Medicine; Haemophilia; Genetic enhancement; Haemophilia A; Virology; Pediatrics; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003558691,0.0004202053,0.0005389951,0.0001971627,0.0007874761,0.0002906622,0.0005468455,0.0002082596,0.001413233],"category_scores_gemma":[0.000195877,0.0002568116,0.0003077325,0.001348782,0.0004962572,0.0001578722,0.0002260736,0.0005847828,0.001431579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001289773,"about_ca_system_score_gemma":0.0003687007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001950121,"about_ca_topic_score_gemma":0.000003043722,"domain_scores_codex":[0.9965336,0.0001167022,0.0004283733,0.000965019,0.001130237,0.0008260276],"domain_scores_gemma":[0.9977188,0.000108814,0.00007676143,0.0008661006,0.0002902065,0.000939334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001613292,0.0009146397,0.02627156,0.0003329967,0.0008052092,0.001438855,0.04418727,0.0001778361,0.3345987,0.0001508915,0.3954396,0.1940692],"study_design_scores_gemma":[0.006487217,0.002089773,0.04738729,0.0003529656,0.0002226125,0.0002922228,0.001565801,0.003319214,0.4094212,0.0007157052,0.526911,0.001235036],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7598965,0.00194143,0.0001746172,0.2348318,0.0005632477,0.001442698,0.00005483254,0.0001911426,0.0009037731],"genre_scores_gemma":[0.9781025,0.0002898537,0.001238413,0.01399988,0.001836693,0.00005404847,0.00005860736,0.00009406448,0.004325958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2208319,"threshold_uncertainty_score":0.9999884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2012430275590101,"score_gpt":0.3568000679925717,"score_spread":0.1555570404335617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}