{"id":"W3085809921","doi":"10.1002/path.5545","title":"Genomic analysis of low‐grade serous ovarian carcinoma to identify key drivers and therapeutic vulnerabilities","year":2020,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Centre Hospitalier de l’Université de Montréal; University of British Columbia","funders":"National Health and Medical Research Council; Terry Fox Research Institute; Cancer Australia","keywords":"CDKN2A; KRAS; Neuroblastoma RAS viral oncogene homolog; Serous carcinoma; Biology; Exome sequencing; Deubiquitinating enzyme; Serous fluid; Cancer research; Targeted therapy; Exome; Ovarian cancer; Comparative genomic hybridization; Oncology; Medicine; Cancer; Mutation; Internal medicine; Gene; Genetics; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002791087,0.0001945757,0.0002334978,0.001372224,0.0002292742,0.0004697915,0.0001257853,0.0002013379,0.00133883],"category_scores_gemma":[0.001007259,0.0001116634,0.000247501,0.0009387227,0.0001689934,0.0001165104,0.0003673068,0.0001828641,0.0002186386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002169044,"about_ca_system_score_gemma":0.0002243327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001646969,"about_ca_topic_score_gemma":0.003044021,"domain_scores_codex":[0.9998457,0.00002477854,0.00001678739,0.00004275208,0.00003906209,0.00003081038],"domain_scores_gemma":[0.9996377,0.0001105118,0.0001022409,0.00005200458,0.00005302103,0.00004444105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005022539,0.00003356603,0.8755627,0.0002129238,0.000239267,0.002124521,0.0002472599,0.0008110665,0.08513061,0.0002720816,0.0007554598,0.03410826],"study_design_scores_gemma":[0.00002343925,0.0001444798,0.9795077,0.00003471945,0.0001900729,0.005450819,0.0002610909,0.001489847,0.008237935,0.0003831937,0.004268007,0.000008653374],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962812,0.0007861965,0.0007228522,0.00006996508,0.000005914757,0.00001656937,0.001447985,0.00003040309,0.0006389212],"genre_scores_gemma":[0.9970539,0.0003439194,0.0006967942,0.00004660555,0.000006208889,0.00001290938,0.001679658,0.000009544081,0.0001504544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001646969,"threshold_uncertainty_score":0.004478872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01932652023255912,"score_gpt":0.2793099446144883,"score_spread":0.2599834243819292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}