{"id":"W3085832865","doi":"10.1001/jamacardio.2020.4120","title":"Genetic Confirmation of Monogenic Familial Hypercholesterolemia Advises a More Intensive Lipid-Lowering Approach—Reply","year":2020,"lang":"en","type":"letter","venue":"JAMA Cardiology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Otorhinolaryngology; Family medicine; Neurology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0002863698,0.0005310866,0.002504112,0.0002500229,0.00006244426,0.00002122922,0.0002916722,0.001268847,0.00001397868],"category_scores_gemma":[0.0004591829,0.000476165,0.001377143,0.0002108472,0.0003024507,0.00006048435,0.0001959718,0.002386722,0.00003911456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000186756,"about_ca_system_score_gemma":0.0004431255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003170757,"about_ca_topic_score_gemma":8.186195e-7,"domain_scores_codex":[0.9965636,0.0004203428,0.000891729,0.00089103,0.0006407168,0.0005925764],"domain_scores_gemma":[0.9974318,0.00009445362,0.0003733938,0.001231584,0.0006853496,0.0001834629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006728678,0.00003197657,0.002118166,0.005589467,0.004873145,0.003695455,0.001291015,0.0003481726,0.003829681,0.000003543096,0.9397066,0.03783989],"study_design_scores_gemma":[0.00420876,0.0009149687,0.02329195,0.0004298686,0.002340808,0.005492754,0.0006685915,0.0003706657,0.0005877817,0.00002233543,0.9609755,0.0006960001],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.3861126,0.01015215,0.013271,0.5750736,0.003189007,0.006018697,0.0005487272,0.0004418352,0.005192334],"genre_scores_gemma":[0.2252322,0.001168437,0.00133405,0.7484507,0.0221133,0.0003057641,0.001111876,0.0001683839,0.0001153169],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1733771,"threshold_uncertainty_score":0.9999148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02307514953294854,"score_gpt":0.2538735782602622,"score_spread":0.2307984287273137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}