{"id":"W3085982958","doi":"10.3233/jpd-202076","title":"Squalamine Restores the Function of the Enteric Nervous System in Mouse Models of Parkinson’s Disease","year":2020,"lang":"en","type":"article","venue":"Journal of Parkinson s Disease","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"","keywords":"Enteric nervous system; Myenteric plexus; In vivo; Motility; Medicine; Neuroscience; Parkinson's disease; Pharmacology; Biology; Internal medicine; Disease; Cell biology; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003724436,0.0003110995,0.0006938041,0.0001894875,0.0000863442,0.0000235121,0.0003943557,0.00006658187,0.00003737917],"category_scores_gemma":[0.0002533385,0.0001768894,0.0006649246,0.0004942502,0.0001301719,0.0002238959,0.0001105851,0.0002933533,0.00000497666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002110602,"about_ca_system_score_gemma":0.0005201094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000420545,"about_ca_topic_score_gemma":0.000007361001,"domain_scores_codex":[0.9968777,0.0003509345,0.00107615,0.0003096077,0.001083001,0.0003025853],"domain_scores_gemma":[0.9970439,0.0000901093,0.001123474,0.0005872439,0.0002868798,0.0008683743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0481205,0.005636424,0.9012831,0.003944549,0.001472491,0.002521655,0.001918382,0.01218375,0.01055922,0.002133542,0.003328006,0.006898387],"study_design_scores_gemma":[0.005090833,0.0006713791,0.9686431,0.0009497826,0.001658261,0.00002353714,0.000738756,0.01053717,0.0008220136,0.0003338134,0.01033661,0.0001947951],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911796,0.005300813,0.0005821125,0.001621161,0.000339634,0.0006551433,0.0002068146,0.00002176064,0.00009298856],"genre_scores_gemma":[0.9986539,0.0003268443,0.00007654397,0.0005128644,0.0002623504,0.00003144932,0.00001057843,0.00004495775,0.000080529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06735995,"threshold_uncertainty_score":0.7213341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02944590233494915,"score_gpt":0.2504059392970365,"score_spread":0.2209600369620874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}