{"id":"W3086046259","doi":"10.2337/db20-0070","title":"Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity","year":2020,"lang":"en","type":"article","venue":"Diabetes","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Münchner Zentrum für Gesundheitswissenschaften; NIHR Oxford Biomedical Research Centre; Helmholtz Zentrum München; National Institutes of Health; Diabetesforeningen; Novo Nordisk Foundation Center for Basic Metabolic Research; FP7 Ideas: European Research Council; Tays; Novo Nordisk Fonden; Diabetesliitto; Sydäntutkimussäätiö; Emil Aaltosen Säätiö; National Center for Advancing Translational Sciences; Medical Research Council; Signe ja Ane Gyllenbergin Säätiö; American Heart Association; Juho Vainion Säätiö; ZonMw; Suomen Kulttuurirahasto; Yrjö Jahnssonin Säätiö; Diabetes UK; Bundesministerium für Gesundheit; National Institute on Minority Health and Health Disparities; Tampereen Tuberkuloosisäätiö; Kela; Johns Hopkins University; European Commission; Li Ka Shing Foundation; Foundation for Cardiovascular Research; Augustinus Fonden; Paavo Nurmen Säätiö; Novo Nordisk; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; Wellcome Trust; Hjerteforeningen; Danmarks Frie Forskningsfond","keywords":"Leptin; Internal medicine; Endocrinology; Adipokine; Biology; Medicine; Obesity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000416726,0.000413898,0.0003729908,0.0009201058,0.0002436511,0.0005041511,0.0002346297,0.0002700221,0.001928657],"category_scores_gemma":[0.001129523,0.0002008128,0.0002461669,0.0009219794,0.0004481169,0.000235423,0.0003457987,0.0003853833,0.000164383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002119569,"about_ca_system_score_gemma":0.0001560806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009165932,"about_ca_topic_score_gemma":0.001014581,"domain_scores_codex":[0.9997512,0.00007030116,0.00002700196,0.00007086342,0.00005565003,0.00002495171],"domain_scores_gemma":[0.9993559,0.0002005712,0.0003142991,0.00003896083,0.00004470478,0.00004568285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001457131,0.0001371728,0.3972188,0.0003844074,0.0008408566,0.00158711,0.0004071619,0.0006498789,0.5550067,0.001285072,0.0002855344,0.04074004],"study_design_scores_gemma":[0.0000448885,0.0004452204,0.9184421,0.00007893414,0.0002422945,0.002290186,0.0002388873,0.001072453,0.07349432,0.001465937,0.00216146,0.0000233243],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913538,0.003471087,0.00335034,0.0001364165,0.00001894487,0.00001148416,0.0005365069,0.00003609334,0.001085388],"genre_scores_gemma":[0.9961571,0.001387063,0.001812712,0.00005474933,0.00001115839,0.00001623987,0.0001930044,0.00001340772,0.0003545372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001928657,"threshold_uncertainty_score":0.006452024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05642881373859547,"score_gpt":0.2831584564927904,"score_spread":0.2267296427541949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}