{"id":"W3086046259","doi":"10.2337/db20-0070","title":"Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity","year":2020,"lang":"en","type":"article","venue":"Diabetes","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Münchner Zentrum für Gesundheitswissenschaften; NIHR Oxford Biomedical Research Centre; Helmholtz Zentrum München; National Institutes of Health; Diabetesforeningen; Novo Nordisk Foundation Center for Basic Metabolic Research; FP7 Ideas: European Research Council; Tays; Novo Nordisk Fonden; Diabetesliitto; Sydäntutkimussäätiö; Emil Aaltosen Säätiö; National Center for Advancing Translational Sciences; Medical Research Council; Signe ja Ane Gyllenbergin Säätiö; American Heart Association; Juho Vainion Säätiö; ZonMw; Suomen Kulttuurirahasto; Yrjö Jahnssonin Säätiö; Diabetes UK; Bundesministerium für Gesundheit; National Institute on Minority Health and Health Disparities; Tampereen Tuberkuloosisäätiö; Kela; Johns Hopkins University; European Commission; Li Ka Shing Foundation; Foundation for Cardiovascular Research; Augustinus Fonden; Paavo Nurmen Säätiö; Novo Nordisk; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; Wellcome Trust; Hjerteforeningen; Danmarks Frie Forskningsfond","keywords":"Leptin; Internal medicine; Endocrinology; Adipokine; Biology; Medicine; Obesity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001128606,0.0000631618,0.0001445992,0.00002645137,0.00005245414,0.00001097341,0.0001744515,0.00002445462,0.00001282718],"category_scores_gemma":[0.0002448007,0.0000482196,0.0000423837,0.0002934421,0.0001738354,0.00008409419,0.00003268495,0.0000507989,0.000008031015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000641055,"about_ca_system_score_gemma":0.00001377565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008371772,"about_ca_topic_score_gemma":0.000003931876,"domain_scores_codex":[0.9991943,0.0001287269,0.0002485127,0.0001537159,0.0001649044,0.0001098708],"domain_scores_gemma":[0.9993826,0.0002632193,0.000138821,0.0001467511,0.00004666027,0.00002190372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00000579206,0.0000278069,0.1710332,0.00002772655,0.000004056933,1.602226e-7,0.001945138,0.0002706655,0.8243974,0.001623445,0.0000989261,0.0005657345],"study_design_scores_gemma":[0.00009326739,0.00005893852,0.5158982,0.00001023681,0.000006379911,5.485228e-8,0.00005874594,0.0004363832,0.4828378,0.0004962833,0.00007459385,0.00002915163],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980761,0.0001740202,0.00002461197,0.001216075,0.00001825191,0.0002051677,0.00001015195,0.00001189767,0.0002636678],"genre_scores_gemma":[0.9994838,0.00003443758,0.0001240359,0.0003086434,0.00002655387,0.000007742799,0.000001319576,0.000003784297,0.000009713247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.344865,"threshold_uncertainty_score":0.1966338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05642881373859547,"score_gpt":0.2831584564927904,"score_spread":0.2267296427541949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}