{"id":"W3086067769","doi":"10.1212/wnl.0000000000010739","title":"Association of amyloid-β CSF/PET discordance and tau load 5 years later","year":2020,"lang":"en","type":"article","venue":"Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Pfizer; Novartis Pharmaceuticals Corporation; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; International Atomic Energy Agency; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Eisai; National Institute on Aging; Alzheimer's Association","keywords":"Medicine; Positron emission tomography; Pet imaging; Internal medicine; Cerebrospinal fluid; Neuroimaging; Nuclear medicine; Cognitive impairment; Dementia; Pathology; Gastroenterology; Disease; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000965016,0.0003568694,0.0004134424,0.0006995311,0.0005973786,0.0007470851,0.0005102672,0.0009730074,0.001172117],"category_scores_gemma":[0.003205255,0.0002918599,0.0005423757,0.0003820379,0.0002060544,0.0006058493,0.0004550699,0.0008072897,0.0002192223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004474465,"about_ca_system_score_gemma":0.0002985699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009034569,"about_ca_topic_score_gemma":0.00702989,"domain_scores_codex":[0.9994861,0.00008596261,0.0000460526,0.0001837873,0.00006899258,0.0001290565],"domain_scores_gemma":[0.9977336,0.0003403225,0.001120918,0.0002023535,0.000285463,0.0003173368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000785997,0.00006272767,0.9974709,0.000003397789,0.00005351514,0.0001448148,0.00006339039,0.00004995996,0.0003236314,0.00001084527,0.00007175213,0.0009591594],"study_design_scores_gemma":[0.000009717443,0.0002222664,0.9988276,0.000003289817,0.00002863083,0.0002582431,0.00008378531,0.0002768824,0.000174445,0.00002342189,0.00008617101,0.000005496533],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995097,0.00009092838,0.00003778365,0.00001917439,0.000005138029,0.000003399244,0.0001814283,0.000003133795,0.0001492768],"genre_scores_gemma":[0.9993039,0.00001868098,0.00003862297,0.00001508437,0.000007407291,0.000004572849,0.0003647515,0.000001586683,0.0002454439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009034569,"threshold_uncertainty_score":0.01796395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01715767912171699,"score_gpt":0.2829621852461465,"score_spread":0.2658045061244295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}