{"id":"W3086067769","doi":"10.1212/wnl.0000000000010739","title":"Association of amyloid-β CSF/PET discordance and tau load 5 years later","year":2020,"lang":"en","type":"article","venue":"Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Pfizer; Novartis Pharmaceuticals Corporation; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; International Atomic Energy Agency; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Eisai; National Institute on Aging; Alzheimer's Association","keywords":"Medicine; Positron emission tomography; Pet imaging; Internal medicine; Cerebrospinal fluid; Neuroimaging; Nuclear medicine; Cognitive impairment; Dementia; Pathology; Gastroenterology; Disease; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003090519,0.0000527356,0.0001487091,0.00001748722,0.00001273365,0.000003537825,0.00002799453,0.00003230889,0.0000843882],"category_scores_gemma":[0.00009247973,0.00004565054,0.00002897477,0.00005755914,0.00004120938,0.00003134414,0.00003357255,0.0001058394,0.00005681062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001189737,"about_ca_system_score_gemma":0.00005173697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000340447,"about_ca_topic_score_gemma":0.00001074101,"domain_scores_codex":[0.9994067,0.0000468453,0.00008719986,0.0001496978,0.0001614605,0.000148089],"domain_scores_gemma":[0.9996588,0.00004670843,0.00004363137,0.00007692063,0.00003937785,0.0001345276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001605794,0.000177745,0.9887753,0.00004699328,0.001041571,0.0007765763,0.000152003,0.000001478726,0.002201001,0.00003272778,0.003817037,0.001371753],"study_design_scores_gemma":[0.001860909,0.001486121,0.9937315,0.000003466667,0.0001664045,0.00002227264,0.000002794533,0.0001269567,0.0004993282,0.0001039664,0.001956885,0.00003937671],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885947,0.0004700739,0.000002085897,0.01031488,0.00002956343,0.0001252885,0.00001861377,0.00001587324,0.0004289801],"genre_scores_gemma":[0.9976414,0.0001323457,0.00002534316,0.002084586,0.00004903277,0.000006041585,0.00001103006,0.00000796542,0.00004229042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009046718,"threshold_uncertainty_score":0.1861575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01715767912171699,"score_gpt":0.2829621852461465,"score_spread":0.2658045061244295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}