{"id":"W3086182462","doi":"10.1007/s11307-020-01540-6","title":"Imaging Butyrylcholinesterase in Multiple Sclerosis","year":2020,"lang":"en","type":"article","venue":"Molecular Imaging and Biology","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saint Mary's University; Mount Saint Vincent University; Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie Medical Research Foundation","keywords":"White matter; Butyrylcholinesterase; Multiple sclerosis; Pathology; Cholinesterase; Microglia; Grey matter; Myelin; Radioligand; Cholinergic; Medicine; Chemistry; Central nervous system; Magnetic resonance imaging; Acetylcholinesterase; In vitro; Internal medicine; Immunology; Enzyme; Biochemistry; Radiology; Aché; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004172631,0.0001374473,0.0002133263,0.00007686702,0.00003546878,0.00002096441,0.00004228336,0.00002236995,0.00001122686],"category_scores_gemma":[0.0001681935,0.000117888,0.00005423866,0.0001375793,0.00008598476,0.00004587977,0.00005670274,0.0001220309,0.000008104092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008318659,"about_ca_system_score_gemma":0.00002326033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003796102,"about_ca_topic_score_gemma":0.000002585196,"domain_scores_codex":[0.9991684,0.00006313898,0.0001711756,0.0003548233,0.00003982935,0.0002026299],"domain_scores_gemma":[0.9996272,0.00003135442,0.00002767068,0.0001136285,0.00003663193,0.0001635344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007362722,0.00003715442,0.4402729,0.00001843854,0.000005240678,0.0002008079,0.0000908967,0.000002687942,0.5530748,0.00001303778,0.0001046246,0.006105825],"study_design_scores_gemma":[0.01360287,0.0002488269,0.5030867,0.0003279965,0.0002021455,0.0004634493,0.0004690608,0.03898974,0.4307302,0.0001402697,0.01081585,0.0009228406],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835211,0.003013415,0.0006219001,0.01252795,0.00004128648,0.0001365075,0.00001557832,0.00004806354,0.00007420179],"genre_scores_gemma":[0.9727956,0.0001004041,0.0002697149,0.02665428,0.0000936924,0.000007187409,0.00005850921,0.00001604126,0.000004544725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1223446,"threshold_uncertainty_score":0.4807334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0650450364291194,"score_gpt":0.2946927248111226,"score_spread":0.2296476883820032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}