{"id":"W3086182462","doi":"10.1007/s11307-020-01540-6","title":"Imaging Butyrylcholinesterase in Multiple Sclerosis","year":2020,"lang":"en","type":"article","venue":"Molecular Imaging and Biology","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saint Mary's University; Mount Saint Vincent University; Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie Medical Research Foundation","keywords":"White matter; Butyrylcholinesterase; Multiple sclerosis; Pathology; Cholinesterase; Microglia; Grey matter; Myelin; Radioligand; Cholinergic; Medicine; Chemistry; Central nervous system; Magnetic resonance imaging; Acetylcholinesterase; In vitro; Internal medicine; Immunology; Enzyme; Biochemistry; Radiology; Aché; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006264696,0.000476194,0.0002777374,0.0008344428,0.0003475467,0.0006278229,0.0005880058,0.001487487,0.001763204],"category_scores_gemma":[0.0005128371,0.0003028264,0.0002055687,0.0003443107,0.0003951218,0.001129613,0.0004405103,0.0008661007,0.0002639858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004140559,"about_ca_system_score_gemma":0.0003738666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0015258,"about_ca_topic_score_gemma":0.001285822,"domain_scores_codex":[0.9999127,0.00003316717,0.000006798717,0.000009267222,0.00001438475,0.00002354779],"domain_scores_gemma":[0.9999108,0.00003676537,0.00001391709,0.000008190947,0.00001432368,0.0000159344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001586445,0.000131997,0.00198382,0.0005682019,0.00008429016,0.00253829,0.0001390538,0.0005101651,0.9507805,0.002102507,0.001020325,0.0385544],"study_design_scores_gemma":[0.0003073645,0.001281519,0.01008182,0.0002129082,0.0003048309,0.01695372,0.0003202804,0.00801283,0.9439046,0.003465957,0.01511721,0.00003682387],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7812825,0.158159,0.03832771,0.005697958,0.0003278156,0.0001769164,0.0002051143,0.0002912285,0.01553167],"genre_scores_gemma":[0.9513621,0.02756792,0.01402123,0.0005620061,0.0001885757,0.0000993198,0.0001360862,0.00004015536,0.006022425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001763204,"threshold_uncertainty_score":0.005898476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0650450364291194,"score_gpt":0.2946927248111226,"score_spread":0.2296476883820032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}