{"id":"W3086193391","doi":"10.1101/2020.09.15.291765","title":"Antitumor immunity in dMMR colorectal cancers requires interferon-induced CCL5 and CXCL10","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Alexandra Hospital; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"CCL5; Cancer research; Immune system; Chemokine; CXCL10; Immune checkpoint; Immunogenicity; Colorectal cancer; Biology; Immunotherapy; Immunology; T cell; Cancer; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001284594,0.0001772224,0.000107468,0.0001316942,0.00007438763,0.0001921449,0.00007432113,0.000121924,0.001339038],"category_scores_gemma":[0.00008373477,0.00005519613,0.0001498144,0.00006702286,0.0001133035,0.0001121201,0.0001375272,0.0004897002,0.0002583505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002168168,"about_ca_system_score_gemma":0.0001967035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002931436,"about_ca_topic_score_gemma":0.0004137568,"domain_scores_codex":[0.999891,0.00002570162,0.0000115242,0.00001651543,0.00001913758,0.00003601038],"domain_scores_gemma":[0.9999019,0.00001228346,0.00002890999,0.00001018417,0.00001017404,0.00003648892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002110115,0.00003895392,0.001626514,0.0000612591,0.000003436312,0.00007409645,0.00001790417,0.00009893976,0.995344,0.0001791528,0.000126623,0.002218142],"study_design_scores_gemma":[0.00008709714,0.001241489,0.05315412,0.00004220226,0.00003518123,0.001339836,0.0002302097,0.004225055,0.9280786,0.0002417538,0.0113154,0.00000913448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959562,0.001162549,0.001286041,0.0001540353,0.00002457748,0.00001836217,0.0002495347,0.00005976611,0.001088906],"genre_scores_gemma":[0.9979208,0.0002542138,0.0006366718,0.00003888656,0.000007759486,0.00002113661,0.0002810268,0.000004828029,0.0008347586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001339038,"threshold_uncertainty_score":0.004479587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02489549154364869,"score_gpt":0.2586879568625896,"score_spread":0.2337924653189409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}