{"id":"W3086197100","doi":"10.1099/mic.0.000971","title":"MexXY RND pump of Pseudomonas aeruginosa PA7 effluxes bi-anionic β-lactams carbenicillin and sulbenicillin when it partners with the outer membrane factor OprA but not with OprM","year":2020,"lang":"en","type":"article","venue":"Microbiology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Foundation","keywords":"Pseudomonas aeruginosa; Carbenicillin; Efflux; Microbiology; Biology; Chemistry; Bacteria; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001511395,0.0003943759,0.0005256544,0.00003297144,0.0000966161,0.00003638824,0.0004337904,0.0003073629,0.00009012908],"category_scores_gemma":[0.00004495255,0.0002372876,0.00009628195,0.00009545996,0.0008172805,0.000009609095,0.0001929079,0.0002197126,0.00001240512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001716921,"about_ca_system_score_gemma":0.0001403613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001006581,"about_ca_topic_score_gemma":0.0003709622,"domain_scores_codex":[0.9981495,0.0001802227,0.0003861466,0.0007220354,0.00009393303,0.0004682107],"domain_scores_gemma":[0.9988727,0.00007891322,0.0002697814,0.0005228836,0.0001304315,0.0001253218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001108151,0.00003416625,0.006057882,0.0000684584,0.0003143464,0.00001547562,0.0005076132,0.00002662305,0.9906198,0.0000339543,0.001099866,0.0001136237],"study_design_scores_gemma":[0.001466252,0.001148938,0.002048625,0.00004011344,0.0001129825,0.0001374997,0.0005025531,0.00001764562,0.9609895,0.000003712132,0.03311646,0.000415669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929928,0.0004386121,0.0005061519,0.005102898,0.00007490923,0.0004352346,0.0002962921,0.00001684319,0.0001363089],"genre_scores_gemma":[0.9959345,0.000273087,0.0008264965,0.00197358,0.0001464892,0.00001116319,0.0002488468,0.00004656453,0.0005392887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03201659,"threshold_uncertainty_score":0.9676306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418148407521474,"score_gpt":0.2299241352147556,"score_spread":0.2157426511395409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}