{"id":"W3086197100","doi":"10.1099/mic.0.000971","title":"MexXY RND pump of Pseudomonas aeruginosa PA7 effluxes bi-anionic β-lactams carbenicillin and sulbenicillin when it partners with the outer membrane factor OprA but not with OprM","year":2020,"lang":"en","type":"article","venue":"Microbiology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Foundation","keywords":"Pseudomonas aeruginosa; Carbenicillin; Efflux; Microbiology; Biology; Chemistry; Bacteria; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382385,0.0003701261,0.00030731,0.0003430268,0.0001433142,0.0003745047,0.0001898647,0.0002929016,0.001019738],"category_scores_gemma":[0.0003551321,0.0001275474,0.0002793744,0.0001899377,0.0001538139,0.0002279676,0.0004384705,0.0004384184,0.000816589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001961265,"about_ca_system_score_gemma":0.0001910894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000824012,"about_ca_topic_score_gemma":0.0005928043,"domain_scores_codex":[0.9996548,0.00008350889,0.00002895987,0.0000373263,0.0001386881,0.00005671696],"domain_scores_gemma":[0.9998418,0.00003651927,0.00003193011,0.00002274885,0.0000393769,0.00002756583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002327259,0.00001927041,0.0006024052,0.00002205955,0.000004501275,0.00005795059,0.00001228418,0.00001826758,0.9980438,0.00006814769,0.00002881567,0.001099142],"study_design_scores_gemma":[0.000004628987,0.00013587,0.01163702,0.00000754758,0.00001345096,0.0008502672,0.00008797165,0.001505052,0.9832507,0.00006467388,0.002432457,0.00001041167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949108,0.001096737,0.002411902,0.0001297213,0.00001847627,0.00001698399,0.0003007626,0.00005491883,0.001059765],"genre_scores_gemma":[0.9931962,0.0004348194,0.002698425,0.00004579841,0.000007047137,0.00002458389,0.001158319,0.00004041518,0.002394354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001019738,"threshold_uncertainty_score":0.003411412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418148407521474,"score_gpt":0.2299241352147556,"score_spread":0.2157426511395409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}