{"id":"W3086236978","doi":"10.1007/s10557-020-07064-z","title":"Spermine Protects Cardiomyocytes from High Glucose-Induced Energy Disturbance by Targeting the CaSR-gp78-Ubiquitin Proteasome System","year":2020,"lang":"en","type":"article","venue":"Cardiovascular Drugs and Therapy","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Laurentian University","funders":"National Natural Science Foundation of China; Heilongjiang Postdoctoral Science Foundation","keywords":"Spermine; MFN2; MFN1; Downregulation and upregulation; Internal medicine; Endocrinology; Mitochondrion; Cell biology; Biology; Medicine; mitochondrial fusion; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002493823,0.0002936482,0.0004419741,0.00001305699,0.0002556349,0.00007778766,0.0002981774,0.0001327082,0.000003324776],"category_scores_gemma":[0.00002367146,0.0002102323,0.0004095455,0.0001507356,0.00008630967,0.000008691439,0.00009471025,0.0001278491,0.000004216143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001001873,"about_ca_system_score_gemma":0.00003724985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004669332,"about_ca_topic_score_gemma":9.599241e-7,"domain_scores_codex":[0.9983438,0.0002106161,0.0002361358,0.0006465968,0.0002598947,0.0003029947],"domain_scores_gemma":[0.999083,0.00001686044,0.00008997649,0.0005836193,0.00007266647,0.0001539058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007257523,0.00002592381,0.00005621075,0.00003551056,0.001167362,0.000007361617,0.000212086,0.00002375542,0.9248697,0.0003246459,0.0008264607,0.0723784],"study_design_scores_gemma":[0.0009071534,0.00005419312,0.0002135181,0.00001195551,0.0000670802,0.000007863384,0.0001800899,0.00008154192,0.6464648,0.0000272873,0.3517294,0.0002551165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8082343,0.1857205,0.004417867,0.0004913264,0.00009656468,0.0007008302,0.0001604494,0.00005082157,0.0001273459],"genre_scores_gemma":[0.9906868,0.006425058,0.0001226022,0.0004681399,0.001391281,0.0005069689,0.0002928369,0.00005101283,0.00005523944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3509029,"threshold_uncertainty_score":0.8573024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007551836849468558,"score_gpt":0.1891933162829996,"score_spread":0.181641479433531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}