{"id":"W3086286620","doi":"10.1016/j.bbadis.2020.165968","title":"Pleiotropic effects of statins: A focus on cancer","year":2020,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":false,"ca_institutions":"Research Institute in Oncology and Hematology; Children's Hospital Research Institute of Manitoba; CancerCare Manitoba; Impact; University of Manitoba; St. Boniface Hospital","funders":"National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences","keywords":"Statin; Cancer; HMG-CoA reductase; Medicine; Prenylation; Pharmacology; Cancer cell; Cancer research; Cholesterol; Cancer prevention; Reductase; Enzyme; Chemistry; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008188218,0.0009629041,0.002168838,0.0002170902,0.00005384215,0.00003293327,0.0008665959,0.000384733,0.00001580279],"category_scores_gemma":[0.0002903797,0.0008719942,0.001931658,0.000450084,0.00027491,0.000008562596,0.0003642114,0.0003327937,0.00001089238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000548615,"about_ca_system_score_gemma":0.001457014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007237072,"about_ca_topic_score_gemma":0.000006031326,"domain_scores_codex":[0.9963009,0.0004649308,0.0009089393,0.00123364,0.0005799737,0.0005116261],"domain_scores_gemma":[0.996801,0.00008122336,0.001040361,0.001371187,0.0001629533,0.0005433321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007936993,0.001287722,8.306371e-7,0.03517085,0.002980275,0.000009128869,0.00008034497,0.000005658361,0.7231684,0.0005427924,0.01099953,0.2249607],"study_design_scores_gemma":[0.001163587,0.0007559957,0.00006726081,0.005504407,0.003948097,0.000001300601,0.000007228589,0.000002548734,0.4466813,0.00006581427,0.5407892,0.001013264],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03080765,0.9630193,0.00005935414,0.0002999726,0.001689112,0.001576169,0.002413069,0.00003187479,0.0001034594],"genre_scores_gemma":[0.02761143,0.9676422,0.0001702804,0.0003780483,0.002682084,0.0004484586,0.000807701,0.0002084859,0.00005127273],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5297897,"threshold_uncertainty_score":0.9993731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01155364191157424,"score_gpt":0.294634325264796,"score_spread":0.2830806833532218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}