{"id":"W3086329702","doi":"10.3390/biom10091318","title":"Postoperative Administration of the Acetylcholinesterase Inhibitor, Donepezil, Interferes with Bone Healing and Implant Osseointegration in a Rat Model","year":2020,"lang":"en","type":"article","venue":"Biomolecules","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute; McGill University","funders":"Fonds de Recherche du Québec - Santé; LEO Pharma; Idorsia Pharmaceuticals; Servier; Faculty of Dentistry, McGill University; Agence Nationale de la Recherche; Alpha Omega Foundation; Réseau de Recherche en Santé Buccodentaire et Osseuse; McGill University","keywords":"Donepezil; Osseointegration; Acetylcholinesterase; Acetylcholinesterase inhibitor; Implant; Medicine; Bone healing; Pharmacology; Dentistry; Anesthesia; Chemistry; Surgery; Internal medicine; Dementia; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003863356,0.0001458651,0.0002158207,0.0000523786,0.00004035877,0.00002765932,0.00003864386,0.00003719133,0.000002057248],"category_scores_gemma":[0.00005756206,0.00008625753,0.00004270252,0.0001782349,0.0001099433,0.0001016229,0.00003130639,0.0000993034,4.691175e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001448817,"about_ca_system_score_gemma":0.0001461747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002463447,"about_ca_topic_score_gemma":0.0002206612,"domain_scores_codex":[0.9992086,0.00005949883,0.000256984,0.0002362705,0.0001382348,0.0001004044],"domain_scores_gemma":[0.9995878,0.0000227647,0.00007790928,0.0001212928,0.00009791375,0.00009230996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002653751,0.0001509173,0.002755202,0.00008716055,0.00001273967,0.00008153683,0.00153811,0.00008933061,0.9918153,0.00015004,0.000140849,0.0005250748],"study_design_scores_gemma":[0.00205895,0.0006030258,0.001685176,0.0003160055,0.00004962094,0.0001912546,0.0005274744,0.009269686,0.9851362,0.000006981359,0.00003708221,0.0001185558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916164,0.0003993458,0.0009477938,0.006552743,0.00002303693,0.0003821763,0.00004571591,0.00001480863,0.00001794232],"genre_scores_gemma":[0.9971386,0.00005631534,0.0003904723,0.002276411,0.00004774585,0.00001636024,0.00004636268,0.00001350344,0.00001422172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009180356,"threshold_uncertainty_score":0.351748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0263903700188382,"score_gpt":0.281651447878643,"score_spread":0.2552610778598048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}