{"id":"W3086558880","doi":"10.1158/1940-6207.capr-20-0186","title":"Evidence that EZH2 Deregulation is an Actionable Therapeutic Target for Prevention of Prostate Cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Prevention Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research; Prostate Cancer Foundation of Australia","keywords":"EZH2; Prostate cancer; Androgen receptor; Cancer research; Cancer; Prostate; Intraepithelial neoplasia; Medicine; Androgen; Phenotype; Biology; Histone; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006907306,0.0001029556,0.0001250452,0.00005931521,0.0001416938,0.00003640616,0.0001630936,0.0001211709,0.0002792068],"category_scores_gemma":[0.00009998155,0.0001039932,0.0001000431,0.0002128307,0.00006651717,0.00003515759,0.00005514426,0.00009696135,0.000002126546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004767478,"about_ca_system_score_gemma":0.0003080277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007497871,"about_ca_topic_score_gemma":0.00007665249,"domain_scores_codex":[0.9985028,0.0002545862,0.000228627,0.0004104974,0.0003598763,0.0002436358],"domain_scores_gemma":[0.9988752,0.00003062317,0.0001811336,0.0002220116,0.0005929585,0.00009806667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004937479,0.00008087727,0.01253272,0.0002378221,0.00008621522,7.973392e-8,0.0003327372,0.001818231,0.854208,0.000080216,0.0007314508,0.1293979],"study_design_scores_gemma":[0.000569235,0.001119511,0.01106162,0.0001153992,0.00002916944,1.169192e-7,0.0001406618,0.002839678,0.9601786,0.00420184,0.01960727,0.000136863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9269198,0.0205917,0.0485891,0.002134523,0.0001356045,0.001473404,0.00006620746,0.00001270032,0.00007692805],"genre_scores_gemma":[0.9893717,0.006018713,0.001075502,0.0000750365,0.0002802426,0.0006311656,0.0001402314,0.000025618,0.002381784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.129261,"threshold_uncertainty_score":0.4240721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2616419683836492,"score_gpt":0.4710813957727604,"score_spread":0.2094394273891111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}