{"id":"W3086558880","doi":"10.1158/1940-6207.capr-20-0186","title":"Evidence that EZH2 Deregulation is an Actionable Therapeutic Target for Prevention of Prostate Cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Prevention Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research; Prostate Cancer Foundation of Australia","keywords":"EZH2; Prostate cancer; Androgen receptor; Cancer research; Cancer; Prostate; Intraepithelial neoplasia; Medicine; Androgen; Phenotype; Biology; Histone; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006171824,0.00031819,0.0002662955,0.0004028977,0.0001103967,0.0003410147,0.0003614675,0.0003886303,0.003866641],"category_scores_gemma":[0.0004271033,0.0001017061,0.0001931868,0.000204021,0.0005128806,0.0003677741,0.0002304476,0.0008161258,0.0004909695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000285307,"about_ca_system_score_gemma":0.0003617561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002597029,"about_ca_topic_score_gemma":0.0005061243,"domain_scores_codex":[0.9998403,0.00004054795,0.00001193349,0.00003359159,0.0000522951,0.00002133152],"domain_scores_gemma":[0.9997488,0.00009001569,0.00005654772,0.00002856011,0.00004509341,0.00003106364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004437153,0.0005617219,0.00682535,0.002354141,0.0004346043,0.0008517647,0.00009958238,0.000758505,0.7204825,0.01790657,0.004332153,0.240956],"study_design_scores_gemma":[0.001405013,0.01001051,0.07038886,0.0006457769,0.001116509,0.004310917,0.0002796109,0.001295533,0.6367017,0.01134535,0.2624363,0.00006400878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5875559,0.3323833,0.01584952,0.01959903,0.001044466,0.000146386,0.001269091,0.0003873806,0.04176487],"genre_scores_gemma":[0.8584477,0.130628,0.002384,0.002424446,0.0005181166,0.00004915978,0.0005541724,0.00002734901,0.004967103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003866641,"threshold_uncertainty_score":0.01293522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2616419683836492,"score_gpt":0.4710813957727604,"score_spread":0.2094394273891111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}