{"id":"W3086663633","doi":"10.1016/s1473-3099(20)30331-5","title":"Safety, immunogenicity, and efficacy of a Clostridioides difficile toxoid vaccine candidate: a phase 3 multicentre, observer-blind, randomised, controlled trial","year":2020,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sanofi (Canada); Vancouver General Hospital","funders":"Sanofi Pasteur; Merck","keywords":"Medicine; Immunogenicity; Clostridioides; Toxoid; Double blind; Internal medicine; Immunology; Vaccination; Alternative medicine; Tetanus; Antibody; Placebo; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003667852,0.002488942,0.004809376,0.0004993487,0.000854333,0.001534201,0.001282188,0.003996765,0.005558848],"category_scores_gemma":[0.00373955,0.0009728817,0.003044419,0.0006561737,0.002457592,0.001528154,0.0005701007,0.003448201,0.001070288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001290125,"about_ca_system_score_gemma":0.001956698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001476214,"about_ca_topic_score_gemma":0.001480578,"domain_scores_codex":[0.9980993,0.000966782,0.0001488203,0.0003568029,0.0001655147,0.000262848],"domain_scores_gemma":[0.9975289,0.0008321436,0.0007163518,0.0002246272,0.0002006687,0.0004973745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9915243,0.002637845,0.0001811413,0.0003834101,0.0004795175,0.00001580365,0.00003464753,0.0001101017,0.001372101,0.00003674897,0.0001814833,0.003042909],"study_design_scores_gemma":[0.9289826,0.06913319,0.0008014965,0.00003017638,0.0003673126,0.00001443606,0.00001320657,0.0001366519,0.0002337558,0.00007144826,0.0002013378,0.00001431103],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877987,0.004089384,0.0009752755,0.0004621701,0.0005553429,0.004375378,0.0007846176,0.00008456827,0.0008745865],"genre_scores_gemma":[0.9841245,0.002502633,0.001712,0.0008853242,0.0005311274,0.007295683,0.0009560317,0.00003192364,0.001960865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005558848,"threshold_uncertainty_score":0.01939768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03200262224993274,"score_gpt":0.3207085801069384,"score_spread":0.2887059578570057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}