{"id":"W3086663633","doi":"10.1016/s1473-3099(20)30331-5","title":"Safety, immunogenicity, and efficacy of a Clostridioides difficile toxoid vaccine candidate: a phase 3 multicentre, observer-blind, randomised, controlled trial","year":2020,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sanofi (Canada); Vancouver General Hospital","funders":"Sanofi Pasteur; Merck","keywords":"Medicine; Immunogenicity; Clostridioides; Toxoid; Double blind; Internal medicine; Immunology; Vaccination; Alternative medicine; Tetanus; Antibody; Placebo; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004108404,0.0004255473,0.001898536,0.0001190581,0.000283664,0.00008286802,0.000315353,0.0001264669,0.0003874654],"category_scores_gemma":[0.003651529,0.0002794995,0.000580923,0.0005751035,0.000203278,0.00008979401,0.0002641788,0.0004738918,0.00002960704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001105581,"about_ca_system_score_gemma":0.0003882483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003040665,"about_ca_topic_score_gemma":0.00003765507,"domain_scores_codex":[0.9968846,0.0003776566,0.0009449192,0.0005152248,0.0006355701,0.0006420086],"domain_scores_gemma":[0.9965371,0.001648158,0.0003516075,0.0006716684,0.0002646795,0.0005267236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9678082,0.002963015,0.003084326,0.000272172,0.001207344,0.00006452306,0.0003175651,0.00005909146,0.01781744,0.00005156414,0.001830641,0.004524059],"study_design_scores_gemma":[0.9769741,0.003477185,0.001652338,0.0001122158,0.001859359,0.00003641844,0.0001506054,0.001360565,0.01279078,0.00001999183,0.001277321,0.000289107],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827941,0.005571526,0.00002517319,0.003213216,0.0001756052,0.006981022,0.0003708407,0.0002153479,0.0006531565],"genre_scores_gemma":[0.9934583,0.003835391,0.000008625765,0.0006175115,0.001514356,0.0002827866,0.0001497948,0.00005179042,0.00008145823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01066417,"threshold_uncertainty_score":0.9999657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03200262224993274,"score_gpt":0.3207085801069384,"score_spread":0.2887059578570057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}