{"id":"W3086729742","doi":"10.1016/j.molcel.2020.08.014","title":"Processive Activity of Replicative DNA Polymerases in the Replisome of Live Eukaryotic Cells","year":2020,"lang":"en","type":"article","venue":"Molecular Cell","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Replisome; Biology; Okazaki fragments; DNA replication; Cell biology; DNA polymerase; Pre-replication complex; Genetics; Saccharomyces cerevisiae; Eukaryotic DNA replication; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004999047,0.0002834812,0.0003131217,0.000557866,0.0003027248,0.0007260096,0.0005855623,0.0003615264,0.001317766],"category_scores_gemma":[0.0008066937,0.0002876116,0.0002392654,0.0002478349,0.0005413819,0.0008355312,0.0002560907,0.0008729821,0.0004888708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003959721,"about_ca_system_score_gemma":0.0002581979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006633836,"about_ca_topic_score_gemma":0.0005362238,"domain_scores_codex":[0.9998239,0.00003307325,0.00001217109,0.00004961925,0.00006250272,0.00001883162],"domain_scores_gemma":[0.9994937,0.0002452944,0.00005898423,0.0000993967,0.00005449119,0.00004813997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002307424,0.00001912463,0.0007204298,0.00007842227,0.00001358565,0.00008657992,0.0001461663,0.0002302052,0.9927338,0.001089183,0.00004609909,0.004605602],"study_design_scores_gemma":[0.00001989885,0.0001911308,0.004611377,0.00001608406,0.00001607019,0.0002499526,0.0000854137,0.001772668,0.9897323,0.0006603108,0.002633368,0.00001128902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701831,0.00681306,0.01942392,0.0001619806,0.00005094147,0.00002741717,0.0003469673,0.000248581,0.002744082],"genre_scores_gemma":[0.9891198,0.001615725,0.005318287,0.00003877986,0.00003993954,0.00002765141,0.0005394734,0.00005930081,0.003241006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001317766,"threshold_uncertainty_score":0.00440836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009103390506665157,"score_gpt":0.2251292150132688,"score_spread":0.2160258245066037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}