{"id":"W3086825036","doi":"10.1111/bjh.17073","title":"Results of a UK National Cancer Research Institute Phase II study of brentuximab vedotin using a response‐adapted design in the first‐line treatment of patients with classical Hodgkin lymphoma unsuitable for chemotherapy due to age, frailty or comorbidity (BREVITY)","year":2020,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Medical Research Council; Takeda Oncology; Blood Cancer UK; National Institute for Health and Care Research; Department of Health and Social Care; Cancer Research UK; Bloodwise; King’s College London; Health Research","keywords":"Medicine; Brentuximab vedotin; Internal medicine; Adverse effect; Confidence interval; Classical Hodgkin lymphoma; Oncology; Surgery; Gastroenterology; Lymphoma; Hodgkin lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006982358,0.0009270731,0.002008076,0.0003567396,0.0003224466,0.0008084002,0.0006594452,0.001216781,0.001370184],"category_scores_gemma":[0.003659461,0.0005324559,0.001315212,0.0005455545,0.001100295,0.0005930722,0.0004103262,0.002429741,0.0004323435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001297068,"about_ca_system_score_gemma":0.001169135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001963829,"about_ca_topic_score_gemma":0.003646175,"domain_scores_codex":[0.9965677,0.00249609,0.0001745175,0.000258611,0.0002464847,0.0002565806],"domain_scores_gemma":[0.9970188,0.0009292185,0.0006407803,0.0004010795,0.0002246915,0.0007855295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6233521,0.05024474,0.02597192,0.001280508,0.004980988,0.0005442947,0.0008118108,0.005990318,0.08537162,0.000316081,0.006992335,0.1941433],"study_design_scores_gemma":[0.2481945,0.662284,0.07686947,0.00006400004,0.001498766,0.0005233167,0.00007854052,0.001106546,0.003530753,0.0001507342,0.005627569,0.00007189243],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884334,0.00449039,0.001322408,0.0006373518,0.0001417408,0.002077862,0.001411382,0.0000854304,0.001400075],"genre_scores_gemma":[0.9852792,0.002546575,0.002644857,0.001166926,0.0001104977,0.002152913,0.004442623,0.00004625852,0.001610235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006982358,"threshold_uncertainty_score":0.03692669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2288983498756854,"score_gpt":0.4219077485188068,"score_spread":0.1930093986431214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}