{"id":"W3086941314","doi":"10.1002/ptr.6814","title":"<scp><i>Lathyrus sativus</i></scp> diamine oxidase reduces <scp><i>Clostridium difficile</i></scp> toxin A‐induced toxicity in Caco‐2 cells by rescuing <scp>RhoA‐GTPase</scp> and inhibiting <scp>pp38‐MAPK</scp>/<scp>NF‐κB</scp>/<scp>HIF</scp>‐1α activation","year":2020,"lang":"en","type":"article","venue":"Phytotherapy Research","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Courtois Foundation","keywords":"Clostridium difficile toxin A; RHOA; Clostridium perfringens; Occludin; Caco-2; Clostridium difficile toxin B; Diamine oxidase; Microbiology; Biology; Viability assay; Tumor necrosis factor alpha; Molecular biology; Clostridium difficile; Pharmacology; Chemistry; Apoptosis; Biochemistry; Signal transduction; Immunology; Tight junction; Cell; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005775395,0.0004166648,0.0002176162,0.0002408309,0.000137408,0.0001474124,0.0001476311,0.0002397182,0.001223663],"category_scores_gemma":[0.00006365317,0.000100603,0.0002549148,0.0001632499,0.0001677338,0.000155119,0.0001278433,0.0004299347,0.0001766132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002061947,"about_ca_system_score_gemma":0.0001795374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001174547,"about_ca_topic_score_gemma":0.001675276,"domain_scores_codex":[0.9999422,0.000008652477,0.000005486652,0.00001181297,0.000016545,0.00001529641],"domain_scores_gemma":[0.9999363,0.00000546937,0.000028496,0.000004430718,0.00000933943,0.00001596584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002206402,0.00002914991,0.00007357946,0.00006602832,0.000007173211,0.00002679277,0.000006004598,0.00002953961,0.9985958,0.00002532825,0.00004658708,0.0008734852],"study_design_scores_gemma":[0.00002240744,0.0006885131,0.004642093,0.000007299941,0.00002648478,0.0001439798,0.00002419052,0.0003326385,0.9918681,0.00001934376,0.002220056,0.000004988317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940246,0.002511342,0.001387828,0.0001538558,0.00003947773,0.00002229803,0.0003739879,0.0001260509,0.001360535],"genre_scores_gemma":[0.9929844,0.001485063,0.001677738,0.0001111254,0.00001719157,0.00002740929,0.0007871132,0.0000306223,0.00287929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001223663,"threshold_uncertainty_score":0.004093528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05323441318144872,"score_gpt":0.3180370052407551,"score_spread":0.2648025920593063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}