{"id":"W3086941314","doi":"10.1002/ptr.6814","title":"<scp><i>Lathyrus sativus</i></scp> diamine oxidase reduces <scp><i>Clostridium difficile</i></scp> toxin A‐induced toxicity in Caco‐2 cells by rescuing <scp>RhoA‐GTPase</scp> and inhibiting <scp>pp38‐MAPK</scp>/<scp>NF‐κB</scp>/<scp>HIF</scp>‐1α activation","year":2020,"lang":"en","type":"article","venue":"Phytotherapy Research","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Courtois Foundation","keywords":"Clostridium difficile toxin A; RHOA; Clostridium perfringens; Occludin; Caco-2; Clostridium difficile toxin B; Diamine oxidase; Microbiology; Biology; Viability assay; Tumor necrosis factor alpha; Molecular biology; Clostridium difficile; Pharmacology; Chemistry; Apoptosis; Biochemistry; Signal transduction; Immunology; Tight junction; Cell; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts","scholarly_communication","research_integrity"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.008773603,0.004032149,0.005013179,0.003862346,0.002943344,0.002196645,0.003398161,0.00292091,0.00009677385],"category_scores_gemma":[0.04894651,0.00414515,0.001486526,0.01178585,0.002252757,0.0021613,0.002435212,0.01119833,0.0007181451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002791511,"about_ca_system_score_gemma":0.003073948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002207049,"about_ca_topic_score_gemma":0.0004524199,"domain_scores_codex":[0.9649922,0.004085304,0.004891863,0.006888195,0.009370851,0.009771534],"domain_scores_gemma":[0.9496444,0.03636534,0.002035412,0.003579843,0.003008697,0.005366275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001614896,0.00323552,0.002711149,0.001466537,0.0008144876,0.0008281392,0.01403148,0.0001836867,0.8134456,0.00009081117,0.159348,0.003683059],"study_design_scores_gemma":[0.01192802,0.004274504,0.002504355,0.001706268,0.0002564223,0.0001525262,0.02603908,0.002208225,0.8659,0.0002247515,0.0844562,0.0003496438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9611587,0.01067942,0.0001867647,0.001930163,0.0007952484,0.008101492,0.001308136,0.001178004,0.01466209],"genre_scores_gemma":[0.9596986,0.01193794,0.0006231178,0.00192878,0.005162942,0.001509309,0.001269723,0.001395065,0.01647455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07489181,"threshold_uncertainty_score":0.9988392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05323441318144872,"score_gpt":0.3180370052407551,"score_spread":0.2648025920593063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}