{"id":"W3086949992","doi":"10.3390/ph13090250","title":"Hybrid Multimodal Imaging Synthons for Chemoselective and Efficient Biomolecule Modification with Chelator and Near-Infrared Fluorescent Cyanine Dye","year":2020,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Deutsche Forschungsgemeinschaft","keywords":"Cyanine; Biomolecule; Synthon; Fluorescence; Combinatorial chemistry; Chemistry; Bioconjugation; Dendrimer; Small molecule; Nanotechnology; Materials science; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002292143,0.0004761433,0.0002350908,0.000243637,0.00008768827,0.0002554332,0.0001831819,0.0003839017,0.0007596496],"category_scores_gemma":[0.0002051033,0.0001751742,0.0001998141,0.0001121467,0.0002142917,0.0003238567,0.0003367065,0.0002768993,0.0004387159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002904099,"about_ca_system_score_gemma":0.0001479308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002375433,"about_ca_topic_score_gemma":0.0004563522,"domain_scores_codex":[0.9998684,0.00002546098,0.0000103926,0.00003113808,0.0000442414,0.00002040843],"domain_scores_gemma":[0.9999022,0.00002208773,0.00003017604,0.000007310651,0.00002264115,0.00001549186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000150907,0.000004988976,0.00002577331,0.00002878195,0.000002541416,0.0000290429,0.000009413807,0.0001245979,0.9986093,0.0002048601,0.00002136495,0.0009241946],"study_design_scores_gemma":[0.000003570599,0.00006380236,0.0001741669,0.000001938068,0.000006091469,0.0001216877,0.000005757275,0.001302168,0.9967657,0.00003005767,0.001519163,0.000005969111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8981643,0.002133233,0.09394686,0.0001989319,0.00005941118,0.0001722853,0.0002556719,0.0004413386,0.004627938],"genre_scores_gemma":[0.9486868,0.001026243,0.0451063,0.0001157099,0.00001974597,0.000125139,0.0002657392,0.00006228645,0.00459188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007596496,"threshold_uncertainty_score":0.002541304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01820986013013115,"score_gpt":0.2666358902778081,"score_spread":0.2484260301476769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}