{"id":"W3087017851","doi":"10.1212/wnl.0000000000010914","title":"<i>C9orf72</i> , age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts","year":2020,"lang":"en","type":"article","venue":"Neurology","topic":"Neurobiology of Language and Bilingualism","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Cambridge Biomedical Research Centre; NIHR Newcastle Biomedical Research Centre; European Regional Development Fund; Instituto de Salud Carlos III; National Institutes of Health; Medical Research Council; Demensfonden; Grifols; Newcastle University; Innovative Medicines Initiative; Universiteit Antwerpen; Vlaamse regering; Norges Forskningsråd; National Institute of Mental Health; Stockholms Läns Landsting; Javna Agencija za Raziskovalno Dejavnost RS; Eisai; Vetenskapsrådet; Alzheimer's Society; Ministero della Salute; Nasjonalforeningen for Folkehelsen; Fonds Wetenschappelijk Onderzoek; University College London Hospitals NHS Foundation Trust; European Commission; UK Dementia Research Institute; European Federation of Pharmaceutical Industries and Associations; University College London; Wellcome Trust; Consortium canadien en neurodégénérescence associée au vieillissement; National Institute on Aging; National Institute for Health and Care Research; Karolinska Institutet; EU Joint Programme – Neurodegenerative Disease Research; Biogen","keywords":"C9orf72; Age of onset; Psychology; Medicine; Gerontology; Dementia; Pathology; Frontotemporal dementia; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001565106,0.0005222143,0.0003659162,0.0008565182,0.0006354352,0.0007572139,0.0003368963,0.0005483739,0.002200431],"category_scores_gemma":[0.003469614,0.0001569692,0.0007908202,0.0006092748,0.0003301738,0.0004427286,0.0007681926,0.0004086237,0.0003363461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002433335,"about_ca_system_score_gemma":0.0002964841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006441766,"about_ca_topic_score_gemma":0.01089073,"domain_scores_codex":[0.9994732,0.0001114103,0.00006928087,0.0002046118,0.00007114432,0.00007048902],"domain_scores_gemma":[0.9988087,0.0003232241,0.0003864577,0.0001884616,0.0001078981,0.0001851848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003662441,0.00002430189,0.9936156,0.00000771023,0.0001008744,0.0001632372,0.0001291666,0.00009604128,0.001663642,0.00003499707,0.0001502042,0.003648046],"study_design_scores_gemma":[0.000009025492,0.0000505075,0.9984344,0.000007882068,0.00005627698,0.0004088675,0.0001081216,0.0003302076,0.0003279714,0.00007991465,0.0001824969,0.000004447762],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987803,0.0001244577,0.0003308952,0.0000355816,0.000005937325,0.000009454514,0.0003495463,0.000009692365,0.0003540893],"genre_scores_gemma":[0.9990101,0.00005313834,0.0003649128,0.00002361186,0.000009354621,0.000007476214,0.0003551085,0.000008545347,0.0001677001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006441766,"threshold_uncertainty_score":0.01280856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05268227322517097,"score_gpt":0.302594732581998,"score_spread":0.249912459356827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}