{"id":"W3087018179","doi":"10.1038/s41586-020-2734-6","title":"Reprogramming roadmap reveals route to human induced trophoblast stem cells","year":2020,"lang":"en","type":"article","venue":"Nature","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":212,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Howard Hughes Medical Institute","keywords":"Reprogramming; Biology; Induced pluripotent stem cell; Stem cell; Cell biology; Somatic cell; Embryonic stem cell; Trophoblast; Chromatin; Cellular differentiation; Genetics; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004685049,0.0003546953,0.0003247568,0.0005749319,0.0004549027,0.002059628,0.0003925629,0.000575786,0.01335644],"category_scores_gemma":[0.000480531,0.0002526052,0.0004727316,0.0004175499,0.0003132396,0.00104219,0.0009064979,0.001266666,0.003546431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007612101,"about_ca_system_score_gemma":0.001291617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008648134,"about_ca_topic_score_gemma":0.0009550929,"domain_scores_codex":[0.9997638,0.00004230142,0.00001887814,0.00006020954,0.00007666207,0.00003827691],"domain_scores_gemma":[0.9998158,0.00004578467,0.00002046319,0.00003190079,0.00004592461,0.00004023349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007195673,0.0001205391,0.005062725,0.0008094811,0.00006091253,0.001619638,0.0006119512,0.003039929,0.525156,0.202879,0.02046294,0.2394573],"study_design_scores_gemma":[0.00005556364,0.0006271591,0.005372455,0.0002043184,0.0001216612,0.002571814,0.0007553085,0.004875134,0.3572139,0.07007972,0.5580783,0.00004463775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.3394664,0.0425134,0.2498165,0.02083395,0.002734444,0.0009009906,0.01483669,0.003692236,0.3252055],"genre_scores_gemma":[0.7559879,0.04346936,0.1163241,0.003094531,0.0004634313,0.0005582771,0.01052435,0.0007870754,0.06879101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01335644,"threshold_uncertainty_score":0.04468179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02152139695961853,"score_gpt":0.2936392247115127,"score_spread":0.2721178277518941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}