{"id":"W3087018179","doi":"10.1038/s41586-020-2734-6","title":"Reprogramming roadmap reveals route to human induced trophoblast stem cells","year":2020,"lang":"en","type":"article","venue":"Nature","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":212,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Howard Hughes Medical Institute","keywords":"Reprogramming; Biology; Induced pluripotent stem cell; Stem cell; Cell biology; Somatic cell; Embryonic stem cell; Trophoblast; Chromatin; Cellular differentiation; Genetics; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001853924,0.0001893497,0.0001935014,0.00004344117,0.0001072277,0.00006141551,0.0004666556,0.00100866,0.00002286993],"category_scores_gemma":[0.00005430825,0.0001803978,0.0001141496,0.0002639994,0.00002004201,0.000003729703,0.0003353155,0.001121745,0.0001169139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002788917,"about_ca_system_score_gemma":0.00004862397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008894805,"about_ca_topic_score_gemma":0.00001136387,"domain_scores_codex":[0.9982802,0.00008802761,0.0002124647,0.0006745519,0.0003331737,0.0004115777],"domain_scores_gemma":[0.998988,0.000007456733,0.00006225063,0.0004801696,0.0001209287,0.0003411745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007105497,0.00002515914,0.0004141629,0.00003719279,0.00003246369,0.00002709985,0.00008136384,0.00001687494,0.9808363,0.00001573599,0.0157253,0.002717236],"study_design_scores_gemma":[0.0003339665,0.0004324462,0.0005844577,0.00001750372,0.000007466812,0.000004188601,0.00006515046,0.00001028491,0.861945,0.00000478447,0.1363923,0.0002024094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956135,0.0005256396,0.00008834481,0.00195589,0.0001367181,0.0004571845,0.00002646141,0.00003860804,0.001157702],"genre_scores_gemma":[0.9936845,0.00001584139,0.0005317762,0.002770005,0.0005368781,0.00002502272,0.00005547747,0.00004093082,0.002339569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.120667,"threshold_uncertainty_score":0.7779713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02152139695961853,"score_gpt":0.2936392247115127,"score_spread":0.2721178277518941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}