{"id":"W3087025265","doi":"10.4049/jimmunol.2000487","title":"Foxp3+ Regulatory T Cell Depletion after Nonablative Oligofractionated Irradiation Boosts the Abscopal Effects in Murine Malignant Mesothelioma","year":2020,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Toronto General Hospital; Toronto Rehabilitation Institute; University of Toronto","funders":"Princess Margaret Cancer Foundation; Uehara Memorial Foundation; Mesothelioma Applied Research Foundation","keywords":"Abscopal effect; FOXP3; Cancer research; CD8; Granzyme B; Cytotoxic T cell; Immune system; Immunology; Medicine; Immunotherapy; Granzyme; Tumor microenvironment; Immune checkpoint; Biology; Perforin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000148669,0.000464196,0.000307478,0.0002636063,0.0001298778,0.0001250769,0.0001752822,0.000196086,0.001009022],"category_scores_gemma":[0.00007339567,0.0001402436,0.0002636497,0.0000875773,0.0002249043,0.0001343675,0.0001395824,0.0007534609,0.000212438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001223478,"about_ca_system_score_gemma":0.0001475389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003167007,"about_ca_topic_score_gemma":0.0005500361,"domain_scores_codex":[0.9998884,0.00001632844,0.000009775006,0.00002667929,0.00002480774,0.00003395809],"domain_scores_gemma":[0.9999183,0.00001062036,0.00002540934,0.0000165827,0.000006694103,0.00002235357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001586426,0.00006956672,0.00009657581,0.00002145062,0.000002730164,0.00002462358,0.000008755057,0.0000808976,0.9983675,0.00003123003,0.0000174358,0.001120553],"study_design_scores_gemma":[0.0000565028,0.001799514,0.002960257,0.000005586927,0.00002642257,0.000174585,0.00001346016,0.001118637,0.9929129,0.00004388181,0.0008849798,0.000003375425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965872,0.0007554748,0.001842703,0.00003493315,0.00002145067,0.0000365755,0.0001059035,0.0001303861,0.0004852537],"genre_scores_gemma":[0.996944,0.0003745814,0.001336648,0.0000346285,0.00001433117,0.0000515432,0.000134602,0.00001791634,0.001091644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001009022,"threshold_uncertainty_score":0.003375471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007790169304986826,"score_gpt":0.2323359127459348,"score_spread":0.224545743440948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}