{"id":"W3087074564","doi":"10.1093/brain/awaa231","title":"Delay from treatment start to full effect of immunotherapies for multiple sclerosis","year":2020,"lang":"en","type":"article","venue":"Brain","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Jerome; Centre intégré de santé et de services sociaux de Chaudière-Appalaches; Université de Montréal","funders":"Sanofi Genzyme; National Health and Medical Research Council; Multiple Sclerosis International Federation; Agence Nationale de la Recherche; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques; Biogen; Merck; Sanofi; Teva Pharmaceutical Industries; Novartis; Roche","keywords":"Multiple sclerosis; Medicine; Psychology; Physical medicine and rehabilitation; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006662873,0.0002863472,0.0007729057,0.000739033,0.0003233135,0.0008605751,0.0005660483,0.0004932367,0.002225021],"category_scores_gemma":[0.01319519,0.0002655134,0.0009611337,0.0006531432,0.0003399912,0.000670463,0.0007081993,0.0007756511,0.0003966049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007063359,"about_ca_system_score_gemma":0.001083564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003293572,"about_ca_topic_score_gemma":0.003829224,"domain_scores_codex":[0.9983614,0.0007325398,0.0001438491,0.0004213894,0.0002261848,0.000114598],"domain_scores_gemma":[0.9902729,0.007000562,0.00152963,0.0008163933,0.0002059012,0.0001745551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01155319,0.0004123053,0.733771,0.0009821216,0.00068185,0.0003496018,0.0009048663,0.03021982,0.006031275,0.005826024,0.00162716,0.2076407],"study_design_scores_gemma":[0.0006555787,0.00428717,0.8865274,0.0003116867,0.001322168,0.001582447,0.000376609,0.06678449,0.01103874,0.008394361,0.01861288,0.0001064092],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9095219,0.004650642,0.07911684,0.0002018524,0.00004399259,0.0003532095,0.003876827,0.0004114315,0.001823242],"genre_scores_gemma":[0.9827254,0.0005666754,0.01280494,0.00007828776,0.0000203996,0.0002546354,0.002884667,0.00005266775,0.000612326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006662873,"threshold_uncertainty_score":0.03523707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09680949445842739,"score_gpt":0.3235899087622342,"score_spread":0.2267804143038068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}