{"id":"W3087085648","doi":"10.1021/acs.jproteome.0c00485","title":"Research on the Human Proteome Reaches a Major Milestone: >90% of Predicted Human Proteins Now Credibly Detected, According to the HUPO Human Proteome Project","year":2020,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; Division of Biological Infrastructure; National Heart, Lung, and Blood Institute; Knut och Alice Wallenbergs Stiftelse; National Institute on Aging; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Health and Medical Research Council; National Institute of General Medical Sciences; Swiss Institute of Bioinformatics","keywords":"Human proteome project; Milestone; Proteome; Human proteins; Computational biology; Biology; Proteomics; Bioinformatics; Geography; Genetics; Archaeology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005942148,0.001205146,0.001060531,0.002519477,0.001257454,0.004298341,0.000700039,0.001573547,0.01047289],"category_scores_gemma":[0.006039024,0.0005394256,0.0009563855,0.003595257,0.001517082,0.003582355,0.00343504,0.004083153,0.01245664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001684971,"about_ca_system_score_gemma":0.003863398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004044542,"about_ca_topic_score_gemma":0.003534469,"domain_scores_codex":[0.998459,0.0002698812,0.00007943185,0.0003418375,0.000698831,0.00015111],"domain_scores_gemma":[0.9932463,0.001637908,0.0004437323,0.0006181381,0.002936453,0.001117356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006114603,0.0001469839,0.006294755,0.002199294,0.0002077468,0.000307892,0.0005483654,0.0002927686,0.07384609,0.01640319,0.4364643,0.4626772],"study_design_scores_gemma":[0.00003498303,0.0002176456,0.01359165,0.0007791977,0.00005933355,0.0005691712,0.0002987286,0.0004807272,0.01712179,0.00843309,0.9583575,0.00005622996],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.07690643,0.3982791,0.1179235,0.1670285,0.02097255,0.0008097508,0.06012594,0.0068396,0.1511146],"genre_scores_gemma":[0.1694084,0.3750469,0.220548,0.05256579,0.01250266,0.0006798702,0.1104027,0.002975065,0.05587062],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01047289,"threshold_uncertainty_score":0.03503531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2081511323511751,"score_gpt":0.451343980964928,"score_spread":0.2431928486137529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}