{"id":"W3087121817","doi":"10.1371/journal.pone.0239153","title":"Reticulon-3 modulates the incorporation of replication competent hepatitis C virus molecules for release inside infectious exosomes","year":2020,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates; Institut national de la recherche scientifique; Armand-Frappier Foundation","keywords":"Microvesicles; Exosome; Biology; Virology; Hepatitis C virus; Gene knockdown; Replicon; Viral replication; Cell culture; Virus; Plasmid; microRNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002139322,0.0002209611,0.000192423,0.0001292861,0.0001162881,0.0002740366,0.0001649394,0.0002171029,0.001089201],"category_scores_gemma":[0.0002001228,0.0001021303,0.0002430372,0.0000797936,0.0002557074,0.0001507639,0.0001629849,0.0003524203,0.0003595722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003548426,"about_ca_system_score_gemma":0.0001525725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003387708,"about_ca_topic_score_gemma":0.0004128684,"domain_scores_codex":[0.9998477,0.00004356195,0.00001497097,0.00002803584,0.00002282317,0.00004297773],"domain_scores_gemma":[0.9998657,0.00002267916,0.00004818393,0.0000143909,0.00001574915,0.00003333751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000284456,0.00003212772,0.0001996605,0.00002115538,0.000003606731,0.00002555889,0.00001178931,0.00002144059,0.9990034,0.00002835937,0.00002852872,0.0003399814],"study_design_scores_gemma":[0.00004129632,0.0004253652,0.007955327,0.000007752158,0.00001497248,0.0001582503,0.00003475313,0.0009166254,0.9893124,0.0000302079,0.001097192,0.000005935295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979406,0.0004996926,0.0006924239,0.00006284125,0.00001898571,0.00001585054,0.0002045174,0.00003300023,0.0005320251],"genre_scores_gemma":[0.9976204,0.0001907331,0.0008341675,0.00004347901,0.000005473521,0.00002498633,0.0003444666,0.00001890169,0.0009173367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001089201,"threshold_uncertainty_score":0.003643811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02806384161309692,"score_gpt":0.2261367572430098,"score_spread":0.1980729156299129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}