{"id":"W3087130502","doi":"10.1002/med.21730","title":"Inhibitors of bromodomain and extra‐terminal proteins for treating multiple human diseases","year":2020,"lang":"en","type":"review","venue":"Medicinal Research Reviews","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Bromodomain; BRD4; BET inhibitor; Epigenetics; Enhancer; Biology; Computational biology; Drug discovery; Transcription factor; Cancer research; Bioinformatics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003128976,0.0006392706,0.0008781177,0.001560635,0.0001710635,0.0004579179,0.0005844604,0.0005960972,0.004440813],"category_scores_gemma":[0.0002668605,0.0001917005,0.0004875282,0.0008796423,0.000217264,0.0005260961,0.0003974557,0.001670584,0.002588249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003358006,"about_ca_system_score_gemma":0.0003787164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004335885,"about_ca_topic_score_gemma":0.001202238,"domain_scores_codex":[0.9998953,0.00001505771,0.0000108182,0.00001540404,0.00004757355,0.00001583589],"domain_scores_gemma":[0.9999118,0.00003650062,0.00001561631,0.000003253631,0.00002048146,0.00001235617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001633873,0.0001872551,0.00009841356,0.01006535,0.0001248482,0.0001995264,0.00004276029,0.0004649836,0.01018601,0.003811233,0.02971203,0.9449442],"study_design_scores_gemma":[0.00006744597,0.0002755295,0.000588787,0.001229212,0.0001131292,0.0011291,0.00001839097,0.0001557741,0.002653673,0.0009631962,0.9927902,0.00001558112],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006457017,0.995449,0.0004434052,0.0002581628,0.0002434118,0.00002097725,0.00005917095,0.00003549382,0.00284455],"genre_scores_gemma":[0.002775311,0.9934155,0.0005285212,0.0002967239,0.0001226579,0.00002471417,0.0001236028,0.000005387814,0.00270758],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004440813,"threshold_uncertainty_score":0.01485598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1648698485161805,"score_gpt":0.4556453076809813,"score_spread":0.2907754591648009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}