{"id":"W3087210672","doi":"10.1158/0008-5472.can-20-0624","title":"Cancers from Novel <i>Pole</i> -Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade","year":2020,"lang":"en","type":"letter","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Hospital for Sick Children; University of Toronto","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Stand Up To Cancer; National Institutes of Health","keywords":"Biology; Carcinogenesis; Cancer research; Phenotype; Cancer; Mutagenesis; Mutation; Genetics; Blockade; Immunotherapy; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001792152,0.0006298667,0.0007090142,0.0002114385,0.0003274173,0.0002080332,0.0008477835,0.0009875915,0.00005589759],"category_scores_gemma":[0.000232816,0.0006299067,0.0002133051,0.0003536447,0.0005625684,0.00001316121,0.000982649,0.001816623,0.00001970241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006004312,"about_ca_system_score_gemma":0.002787192,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03155219,"about_ca_topic_score_gemma":0.002014183,"domain_scores_codex":[0.9957954,0.0001644954,0.0006294815,0.001608032,0.0008092857,0.0009933608],"domain_scores_gemma":[0.997791,0.0001913061,0.0002176986,0.001016744,0.0003844139,0.0003988296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000260833,0.00003159658,0.00001480898,0.0001835768,0.0003411856,0.0001428958,0.0003765256,0.0002980318,0.88267,0.000004250478,0.1149685,0.0007077465],"study_design_scores_gemma":[0.000950489,0.0001836465,0.000005506651,0.00009412965,0.0000642654,0.000004027211,0.00007172701,0.0006684156,0.5514176,0.0001919066,0.4457878,0.0005604982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6183622,0.09481647,0.00040005,0.2781112,0.0007604013,0.001747876,0.005473507,0.00006880679,0.0002594775],"genre_scores_gemma":[0.5018466,0.114321,0.000772944,0.3444,0.02121465,0.002607928,0.01087515,0.0009223307,0.003039361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3312525,"threshold_uncertainty_score":0.9996153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03610922189717269,"score_gpt":0.2932745242812809,"score_spread":0.2571653023841082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}