{"id":"W3087210672","doi":"10.1158/0008-5472.can-20-0624","title":"Cancers from Novel <i>Pole</i> -Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade","year":2020,"lang":"en","type":"letter","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Hospital for Sick Children; University of Toronto","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Stand Up To Cancer; National Institutes of Health","keywords":"Biology; Carcinogenesis; Cancer research; Phenotype; Cancer; Mutagenesis; Mutation; Genetics; Blockade; Immunotherapy; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001802762,0.0005594027,0.0005448379,0.000378568,0.0007289321,0.001017222,0.0006490376,0.009857411,0.002627674],"category_scores_gemma":[0.002609236,0.0003265724,0.0005997762,0.000194225,0.001207108,0.0007808402,0.0003700568,0.008439296,0.002144183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001588126,"about_ca_system_score_gemma":0.0005771511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001151406,"about_ca_topic_score_gemma":0.002213644,"domain_scores_codex":[0.9992713,0.0002450671,0.00006699403,0.0001129462,0.000223971,0.00007973086],"domain_scores_gemma":[0.9983082,0.001133396,0.00009963002,0.00009332938,0.0002219171,0.0001434998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000686878,0.0001239275,0.001520738,0.0001835535,0.00004086545,0.01764727,0.0001414555,0.0002822629,0.0199277,0.00967878,0.9203931,0.02937356],"study_design_scores_gemma":[0.0005488944,0.0005114731,0.004908253,0.0001910964,0.00008107373,0.02051879,0.0002103185,0.002348105,0.01718296,0.01544047,0.9379451,0.0001134134],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.01429829,0.007773013,0.00307757,0.9112225,0.04404825,0.0001461388,0.0004842526,0.0005393974,0.01841052],"genre_scores_gemma":[0.07995074,0.008500249,0.00265505,0.7958014,0.06337319,0.000270522,0.0002415089,0.0001927944,0.04901462],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.009857411,"threshold_uncertainty_score":0.01152265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03610922189717269,"score_gpt":0.2932745242812809,"score_spread":0.2571653023841082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}