{"id":"W3087227263","doi":"10.1002/acn3.51196","title":"Discordant Alzheimer's neurodegenerative biomarkers and their clinical outcomes","year":2020,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; National Natural Science Foundation of China; Fudan University; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Roche; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Drug Discovery Foundation; IXICO; Takeda Pharmaceutical Company; AbbVie; Fujirebio Europe; Alzheimer's Association; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Medicine; Clinical Dementia Rating; Alzheimer's Disease Neuroimaging Initiative; Internal medicine; Entorhinal cortex; Atrophy; Neuroimaging; Dementia; Oncology; Hazard ratio; Cognition; Cognitive decline; Disease; Hippocampus; Psychiatry; Confidence interval","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007462206,0.0004019841,0.0003281779,0.0008907748,0.0004912484,0.0005886783,0.0004086073,0.0005731974,0.0008615945],"category_scores_gemma":[0.002673571,0.000158419,0.0002867592,0.0006555376,0.0003101252,0.0003549805,0.000414204,0.0004010274,0.0001676356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002796849,"about_ca_system_score_gemma":0.0002469358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001488037,"about_ca_topic_score_gemma":0.002049416,"domain_scores_codex":[0.9996215,0.0001055805,0.00005836314,0.00009211086,0.00006202221,0.00006046669],"domain_scores_gemma":[0.9979401,0.0001766035,0.00141891,0.00008408739,0.0001878661,0.0001924611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001785697,0.00001990311,0.9989591,0.000007975677,0.0000386793,0.00008666425,0.00002031491,0.00001354515,0.00005813975,0.000007682198,0.00003573878,0.0005735953],"study_design_scores_gemma":[0.00001095468,0.00008420058,0.9984689,0.00001121752,0.0000430666,0.0009898652,0.00005926087,0.00008930903,0.0001047199,0.00004395012,0.0000917439,0.000002637591],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989767,0.0004189799,0.00003558151,0.00002604311,0.000004457517,0.000006368654,0.0002217863,0.000001721163,0.0003084645],"genre_scores_gemma":[0.9996362,0.00004618663,0.00003646294,0.000009992408,0.000005114293,0.000004349544,0.0002070314,4.220668e-7,0.00005437524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001488037,"threshold_uncertainty_score":0.003946424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2686267075128452,"score_gpt":0.4724674429438193,"score_spread":0.203840735430974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}