{"id":"W3087245118","doi":"10.1126/sciimmunol.abb8786","title":"Transcriptomic and clonal characterization of T cells in the human central nervous system","year":2020,"lang":"en","type":"article","venue":"Science Immunology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; Race to Erase MS; National Multiple Sclerosis Society; National Cancer Institute; National Science Foundation; National Institutes of Health; National Human Genome Research Institute; Nancy Taylor Foundation for Chronic Diseases","keywords":"Transcriptome; Central nervous system; Cerebrospinal fluid; T-cell receptor; Biology; T cell; RNA; Immunology; Cell biology; Gene; Immune system; Neuroscience; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001924988,0.00007076434,0.0001003772,0.00009283699,0.0001802575,0.0000475146,0.0003880959,0.00002610168,0.00001218905],"category_scores_gemma":[0.00005182433,0.00005511592,0.00001756801,0.0005076788,0.0003992688,0.000227074,0.00003372039,0.0001119579,0.000008284001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001264191,"about_ca_system_score_gemma":0.00004841731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000372849,"about_ca_topic_score_gemma":0.000001124281,"domain_scores_codex":[0.9988972,0.0001872113,0.000229318,0.0002837753,0.0002017383,0.0002007596],"domain_scores_gemma":[0.9996967,0.00003081763,0.00009241293,0.0001266383,0.00001868722,0.00003472694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008589178,0.0000100869,0.00003226243,0.000008458504,1.88892e-7,0.000005531401,0.001252669,0.00001184172,0.9605888,0.03787721,0.000001778758,0.0002025934],"study_design_scores_gemma":[0.0001963549,0.00009462721,0.01316842,0.000003880155,0.000001511681,0.00002769163,0.000133549,0.002284695,0.9839066,0.00003340593,0.000100862,0.00004844354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976897,0.00000391443,0.0003402469,0.001323449,0.0002696988,0.00019621,0.000006582377,0.00003068236,0.0001395055],"genre_scores_gemma":[0.998885,0.00001255942,0.00001644581,0.001044273,0.00002090585,0.000005565282,0.000001157855,0.000004126934,0.000009951559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0378438,"threshold_uncertainty_score":0.2247562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02834756945987705,"score_gpt":0.234360215463339,"score_spread":0.206012646003462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}