{"id":"W3087247858","doi":"10.1038/s41419-020-02944-6","title":"BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models","year":2020,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto; Sunnybrook Hospital","funders":"Vlaamse regering; Kom op tegen Kanker; Associazione Italiana per la Ricerca sul Cancro; Canadian Institutes of Health Research; KU Leuven; Fonds Wetenschappelijk Onderzoek; Bijzonder Onderzoeksfonds UGent; Government of Canada","keywords":"Venetoclax; Apoptosis; Cancer research; Programmed cell death; Cancer; Protein kinase B; Chronic lymphocytic leukemia; MCL1; Cell culture; Cancer cell; Biology; PI3K/AKT/mTOR pathway; Cell; Bcl-2-associated X protein; Downregulation and upregulation; Chemistry; Leukemia; Immunology; Caspase 3; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009546497,0.0003325595,0.0003455431,0.0002383896,0.0001953008,0.0001939095,0.0001592588,0.0002295376,0.001320188],"category_scores_gemma":[0.00005659354,0.0001035173,0.0002394539,0.000217277,0.0001460219,0.000186594,0.0001137507,0.0006428815,0.0003256329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000236387,"about_ca_system_score_gemma":0.0001835758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005568856,"about_ca_topic_score_gemma":0.0007952316,"domain_scores_codex":[0.9999062,0.00001960238,0.000009645204,0.00001523666,0.00002742997,0.00002190594],"domain_scores_gemma":[0.9999645,0.00000686172,0.000008511181,0.000004875768,0.00000536446,0.00000999691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003853283,0.00008182759,0.0001053099,0.00007279098,0.00001063071,0.00003246457,0.00001215092,0.00008409296,0.9967488,0.0001158858,0.00009485389,0.002255865],"study_design_scores_gemma":[0.00005328795,0.0008622404,0.001115343,0.000003467984,0.00002209943,0.0002465537,0.00001417374,0.0005244479,0.9934721,0.00005258783,0.003628977,0.000004703521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859271,0.006862378,0.003612059,0.000186956,0.0000726367,0.00006517454,0.0006939354,0.0002040497,0.002375695],"genre_scores_gemma":[0.9916856,0.002768025,0.00217106,0.00007553963,0.0000124174,0.00005739545,0.0009137359,0.00001202077,0.002304243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001320188,"threshold_uncertainty_score":0.004416466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01403056165620724,"score_gpt":0.240494776164063,"score_spread":0.2264642145078557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}