{"id":"W3087247858","doi":"10.1038/s41419-020-02944-6","title":"BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models","year":2020,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto; Sunnybrook Hospital","funders":"Vlaamse regering; Kom op tegen Kanker; Associazione Italiana per la Ricerca sul Cancro; Canadian Institutes of Health Research; KU Leuven; Fonds Wetenschappelijk Onderzoek; Bijzonder Onderzoeksfonds UGent; Government of Canada","keywords":"Venetoclax; Apoptosis; Cancer research; Programmed cell death; Cancer; Protein kinase B; Chronic lymphocytic leukemia; MCL1; Cell culture; Cancer cell; Biology; PI3K/AKT/mTOR pathway; Cell; Bcl-2-associated X protein; Downregulation and upregulation; Chemistry; Leukemia; Immunology; Caspase 3; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007921034,0.000171342,0.0002330351,0.00003208136,0.00004000106,0.00001302249,0.0001088793,0.0001281728,0.00002243908],"category_scores_gemma":[0.00001221836,0.0001547438,0.00009858049,0.0000988609,0.00005879278,0.00001326135,0.00009775809,0.00006536215,4.937135e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001291876,"about_ca_system_score_gemma":0.0001929328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002930682,"about_ca_topic_score_gemma":0.00002615841,"domain_scores_codex":[0.9989519,0.00005521809,0.00028418,0.0003695371,0.0001551649,0.000184023],"domain_scores_gemma":[0.9992907,0.00000977004,0.0001572473,0.0001600138,0.00006436084,0.000317921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007365116,0.0003234058,0.002910811,0.0004805156,0.00003623242,0.000006911274,0.0008769607,0.001807421,0.9910527,0.0005212717,0.0001046129,0.001142571],"study_design_scores_gemma":[0.004073632,0.0005278994,0.005988439,0.00006892394,0.0001674943,8.014301e-7,0.001229801,0.007159841,0.9736607,0.005638677,0.0009377799,0.0005459971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872417,0.007979977,0.003164821,0.0001006907,0.00004412496,0.0002916167,0.0002599445,0.000005574406,0.0009115456],"genre_scores_gemma":[0.996748,0.002160898,0.0005310095,0.0001843649,0.00005185438,0.00002873156,0.0001507309,0.00001755837,0.0001268771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01739206,"threshold_uncertainty_score":0.6310271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01403056165620724,"score_gpt":0.240494776164063,"score_spread":0.2264642145078557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}