{"id":"W3087273430","doi":"10.1016/j.bja.2020.08.046","title":"Perioperative genetic screening: entering a new era","year":2020,"lang":"en","type":"letter","venue":"British Journal of Anaesthesia","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Butyrylcholinesterase; Pharmacogenetics; Phenotype; Malignant hyperthermia; Genetics; Genotype; Medicine; Gene; Biology; Anesthesia; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003690782,0.0006523979,0.001158297,0.001058022,0.002009513,0.00340647,0.001154156,0.03127227,0.006969189],"category_scores_gemma":[0.01663128,0.0003800046,0.0008657891,0.0006596486,0.00326585,0.005254423,0.001844396,0.02315478,0.002351797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002629142,"about_ca_system_score_gemma":0.003667047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002720991,"about_ca_topic_score_gemma":0.005304377,"domain_scores_codex":[0.9963946,0.001277648,0.0003964918,0.0004312629,0.001045891,0.0004542329],"domain_scores_gemma":[0.9833226,0.009640834,0.0008583363,0.0004073607,0.001940673,0.003830194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002197214,0.000128381,0.004811947,0.0003635607,0.00003984315,0.0239227,0.0005419895,0.0002454208,0.001637591,0.01351878,0.8608486,0.09372158],"study_design_scores_gemma":[0.000140462,0.0002447056,0.00555478,0.001415972,0.00005516521,0.04145177,0.001343929,0.0008944056,0.000336648,0.03803681,0.9104095,0.0001160828],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0008959436,0.007362578,0.0004158975,0.9792628,0.0078621,0.000006424363,0.00002482508,0.00002650266,0.004142909],"genre_scores_gemma":[0.02081238,0.02049432,0.001662228,0.8239034,0.1256655,0.00003015585,0.000062097,0.00004551571,0.007324398],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03127227,"threshold_uncertainty_score":0.02331424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09446561631948286,"score_gpt":0.3707480576377384,"score_spread":0.2762824413182556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}