{"id":"W3087330846","doi":"10.1101/2020.09.01.20180406","title":"Genomic and phenomic insights from an atlas of genetic effects on DNA methylation","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Holland Bloorview Kids Rehabilitation Hospital; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Economic and Social Research Council; Medical Research Council","keywords":"dNaM; Biology; Quantitative trait locus; DNA methylation; Genetics; Genetic architecture; Evolutionary biology; Computational biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003029717,0.000145435,0.0002403918,0.001148194,0.000179548,0.0004374197,0.000169944,0.0002294776,0.002405634],"category_scores_gemma":[0.0006365757,0.0001399237,0.0002166019,0.00123723,0.000237491,0.0002171084,0.0005080759,0.0002426721,0.0003137074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000196556,"about_ca_system_score_gemma":0.0001533966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001627769,"about_ca_topic_score_gemma":0.002842764,"domain_scores_codex":[0.9998053,0.00003634256,0.000007202009,0.00009305353,0.00003461758,0.00002368042],"domain_scores_gemma":[0.9996655,0.0001082664,0.00009156435,0.00006960324,0.00002419395,0.00004097519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008318838,0.00004916484,0.2358916,0.000295393,0.0005021269,0.0005419058,0.000517371,0.009931756,0.6818232,0.007271288,0.002394207,0.05995013],"study_design_scores_gemma":[0.00003204238,0.0001185953,0.9023711,0.00002310137,0.000260153,0.0008976001,0.0002448322,0.0191377,0.04745214,0.01701624,0.01240767,0.00003883907],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9561024,0.0007522543,0.02693809,0.0002106204,0.00001446369,0.000009836173,0.01332949,0.000361651,0.002281227],"genre_scores_gemma":[0.9784254,0.0003679313,0.01374363,0.00006768072,0.0000189047,0.00001915801,0.005851823,0.00008030565,0.001425107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002405634,"threshold_uncertainty_score":0.0080477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01435204682075377,"score_gpt":0.2567282282203235,"score_spread":0.2423761813995698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}