{"id":"W3087354066","doi":"10.1093/cid/ciaa1403","title":"Risk of Incident Diabetes Mellitus, Weight Gain, and Their Relationships With Integrase Inhibitor–Based Initial Antiretroviral Therapy Among Persons With Human Immunodeficiency Virus in the United States and Canada","year":2020,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McGill University; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of Nursing Research; National Institute on Deafness and Other Communication Disorders; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism; Canadian Institutes of Health Research; Ontario Ministry of Health and Long-Term Care; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Health Resources and Services Administration; National Institute of Dental and Craniofacial Research; Centers for Disease Control and Prevention; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Government of Alberta; Agency for Healthcare Research and Quality; National Institutes of Health","keywords":"Medicine; Cart; Hazard ratio; Regimen; Internal medicine; Integrase inhibitor; Raltegravir; Proportional hazards model; Diabetes mellitus; Reverse-transcriptase inhibitor; Viral load; Cohort; Weight change; Confidence interval; Immunology; Weight loss; Antiretroviral therapy; Endocrinology; Human immunodeficiency virus (HIV); Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004772427,0.0002758161,0.0003109759,0.0008779977,0.00128108,0.001019279,0.0008925871,0.0003339333,0.00184931],"category_scores_gemma":[0.002448762,0.0002591815,0.0006068549,0.001792212,0.0002933365,0.0003016677,0.0006170963,0.001075507,0.0001556191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005756277,"about_ca_system_score_gemma":0.008995332,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.923247,"about_ca_topic_score_gemma":0.9213783,"domain_scores_codex":[0.999486,0.00003993967,0.0000382765,0.00008343087,0.000186195,0.0001661813],"domain_scores_gemma":[0.9981907,0.0001273245,0.000484727,0.00006866609,0.0005563044,0.0005721882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000307034,0.00001746585,0.9989145,0.000003521027,0.00002302363,0.00002210479,0.00002824896,0.00002943619,0.00001372537,0.00001455009,0.0001936267,0.0007092137],"study_design_scores_gemma":[0.000005218293,0.00001278496,0.9991395,0.00001158721,0.00003131304,0.00005819431,0.0001767786,0.0002867898,0.00001915563,0.00001995325,0.000234598,0.000003980984],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927245,0.001052896,0.00006293215,0.0003923555,0.00001473653,0.00003759557,0.003281453,0.00001156057,0.002421996],"genre_scores_gemma":[0.9975696,0.0006005869,0.0001070473,0.00005746293,0.00001040623,0.00001205639,0.001148572,0.000002622474,0.0004914675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07675296,"threshold_uncertainty_score":0.1544099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02924397467566771,"score_gpt":0.3081144145466445,"score_spread":0.2788704398709768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}