{"id":"W3087354066","doi":"10.1093/cid/ciaa1403","title":"Risk of Incident Diabetes Mellitus, Weight Gain, and Their Relationships With Integrase Inhibitor–Based Initial Antiretroviral Therapy Among Persons With Human Immunodeficiency Virus in the United States and Canada","year":2020,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McGill University; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of Nursing Research; National Institute on Deafness and Other Communication Disorders; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism; Canadian Institutes of Health Research; Ontario Ministry of Health and Long-Term Care; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Health Resources and Services Administration; National Institute of Dental and Craniofacial Research; Centers for Disease Control and Prevention; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Government of Alberta; Agency for Healthcare Research and Quality; National Institutes of Health","keywords":"Medicine; Cart; Hazard ratio; Regimen; Internal medicine; Integrase inhibitor; Raltegravir; Proportional hazards model; Diabetes mellitus; Reverse-transcriptase inhibitor; Viral load; Cohort; Weight change; Confidence interval; Immunology; Weight loss; Antiretroviral therapy; Endocrinology; Human immunodeficiency virus (HIV); Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002291281,0.0001907448,0.0003627376,0.0001019724,0.0003427461,0.00002636077,0.00006341306,0.00006878572,0.00000766367],"category_scores_gemma":[0.0002784006,0.0001019611,0.00004808189,0.0004305806,0.0005271056,0.0000647551,0.00001807103,0.0004974828,4.238578e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005325618,"about_ca_system_score_gemma":0.000373764,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.1096938,"about_ca_topic_score_gemma":0.08908711,"domain_scores_codex":[0.9984126,0.0004798286,0.0004586536,0.0002868919,0.0001680048,0.0001940274],"domain_scores_gemma":[0.9979656,0.001209762,0.0002413427,0.0002306587,0.000121415,0.0002312742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000196587,0.0006609196,0.9976363,0.00004375344,0.0001305893,0.0000186814,0.0006330254,0.00005638747,0.000008147371,0.0000351192,0.00007657777,0.0005038988],"study_design_scores_gemma":[0.003330865,0.003104545,0.9898174,0.0001795981,0.0002293034,0.000001897011,0.001030997,0.002000254,0.00005261664,0.00006502032,0.00006954266,0.0001179314],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971073,0.001402307,0.00004357204,0.0005298029,0.00001530345,0.0006187909,0.0002063655,0.00003583016,0.00004071681],"genre_scores_gemma":[0.9979049,0.0008725956,0.000009566486,0.0008497612,0.00003139235,0.00005960276,0.0002526256,0.00001828808,0.0000012762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02060669,"threshold_uncertainty_score":0.9275347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02924397467566771,"score_gpt":0.3081144145466445,"score_spread":0.2788704398709768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}