{"id":"W3087393791","doi":"10.1016/s0140-6736(20)31953-x","title":"Neoadjuvant atezolizumab in combination with sequential nab-paclitaxel and anthracycline-based chemotherapy versus placebo and chemotherapy in patients with early-stage triple-negative breast cancer (IMpassion031): a randomised, double-blind, phase 3 trial","year":2020,"lang":"en","type":"article","venue":"The Lancet","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1060,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"F. Hoffmann-La Roche","keywords":"Medicine; Atezolizumab; Anthracycline; Oncology; Chemotherapy; Internal medicine; Placebo; Nab-paclitaxel; Breast cancer; Triple-negative breast cancer; Paclitaxel; Stage (stratigraphy); Cancer; Immunotherapy; Pembrolizumab; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002081356,0.002200961,0.004019215,0.0004455651,0.0004378583,0.001294189,0.001277825,0.002201244,0.006801525],"category_scores_gemma":[0.001797199,0.001026728,0.002709029,0.0004834468,0.001658098,0.001432285,0.0005301726,0.004568368,0.001392563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009520384,"about_ca_system_score_gemma":0.001251471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001105834,"about_ca_topic_score_gemma":0.002643605,"domain_scores_codex":[0.999307,0.0003990193,0.00003813179,0.0001154827,0.00003622844,0.000104139],"domain_scores_gemma":[0.9989489,0.0003508018,0.0002032991,0.0001026551,0.00004591902,0.0003484882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9879786,0.002851989,0.0001791719,0.0002712424,0.000455225,0.0000136881,0.00002379384,0.0002052334,0.001184367,0.00005043987,0.0003144433,0.006471817],"study_design_scores_gemma":[0.9324244,0.06562251,0.0006901463,0.00002243926,0.0003127941,0.00002225379,0.000017558,0.0002300501,0.0002494185,0.00009872361,0.0002958364,0.00001394438],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857966,0.005709587,0.0007647375,0.001137785,0.001229519,0.002124711,0.001002782,0.0001514172,0.002082736],"genre_scores_gemma":[0.9820446,0.003728739,0.001544654,0.001509579,0.000790454,0.003280255,0.001315467,0.00004979132,0.00573651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006801525,"threshold_uncertainty_score":0.02275336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02791968987241577,"score_gpt":0.308306646219802,"score_spread":0.2803869563473863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}