{"id":"W3087398517","doi":"10.1038/s41396-020-00774-0","title":"Quorum sensing controls persistence, resuscitation, and virulence of <i>Legionella</i> subpopulations in biofilms","year":2020,"lang":"en","type":"article","venue":"The ISME Journal","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Stiftung für Medizinisch-Biologische Forschung; Deutsche Forschungsgemeinschaft; McGill University; Novartis Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Legionella pneumophila; Biology; Biofilm; Legionella; Virulence; Quorum sensing; Microbiology; Pathogen; Pseudomonas aeruginosa; Legionnaires' disease; Bacteria; Multidrug tolerance; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000325055,0.00006467835,0.00009788245,0.00003459164,0.0001311162,0.0000311479,0.0001241755,0.00004729284,0.000002855683],"category_scores_gemma":[0.0001396425,0.00004588501,0.00004555041,0.0001357682,0.0001387986,0.000007044528,0.00005175187,0.0001631475,0.000001558327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005817493,"about_ca_system_score_gemma":0.00006628912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002569226,"about_ca_topic_score_gemma":0.00002387036,"domain_scores_codex":[0.9992825,0.0001032198,0.0002005725,0.0001152761,0.0001466947,0.0001517622],"domain_scores_gemma":[0.9996115,0.00003051379,0.00009245038,0.00009395858,0.00009377028,0.00007783521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001177274,0.00001292193,0.01088304,0.00001057357,0.00002304465,0.000006390364,0.0006037651,0.0003387881,0.9855663,0.0001057908,0.0015643,0.0007674198],"study_design_scores_gemma":[0.01253416,0.002647724,0.1852983,0.0004897854,0.000208593,0.00150936,0.01956047,0.03058742,0.7006896,0.004756195,0.04025222,0.001466105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852632,0.0006873662,0.0005494733,0.01307246,0.00004438827,0.00008297619,0.000004246464,0.000002014826,0.0002938691],"genre_scores_gemma":[0.9983701,0.0004860869,0.0002970276,0.000608858,0.000172612,5.10251e-7,0.000003532857,0.000006352865,0.00005494861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2848766,"threshold_uncertainty_score":0.1871136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03255818185666919,"score_gpt":0.2638603249347753,"score_spread":0.2313021430781061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}