{"id":"W3087426948","doi":"10.1016/j.jhep.2020.09.011","title":"A placebo-controlled randomised trial of budesonide for PBC following an insufficient response to UDCA","year":2020,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University Health Network","funders":"Dr. Falk Pharma","keywords":"Budesonide; Placebo response; Medicine; Placebo; Internal medicine; Corticosteroid; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001470869,0.0001189067,0.0012057,0.0001729266,0.00005078563,0.000008674127,0.0001575149,0.00008272509,0.00004595345],"category_scores_gemma":[0.005101489,0.00008650919,0.0007464887,0.0001293223,0.00002931152,0.00006748961,0.00003090726,0.0001745294,0.000003244053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005812152,"about_ca_system_score_gemma":0.000638106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009136666,"about_ca_topic_score_gemma":0.000002010815,"domain_scores_codex":[0.9980419,0.0005328468,0.0008604181,0.0001181494,0.0002375038,0.0002092418],"domain_scores_gemma":[0.9977854,0.0009904591,0.0004349453,0.0001638028,0.0002402027,0.0003851542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9599749,0.0006510469,0.002721741,0.00003688509,0.0004532515,0.0001161678,0.0008916274,0.00002305838,0.03409752,0.00001136169,0.0005600421,0.0004623753],"study_design_scores_gemma":[0.9649359,0.02518982,0.001478507,0.00006680869,0.00107116,0.00008391079,0.0003911248,0.001407379,0.002293291,0.00002276702,0.002960776,0.00009855322],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905088,0.000210184,0.001054224,0.006055128,0.0004496027,0.001643982,0.000007363266,0.000008455018,0.00006226437],"genre_scores_gemma":[0.9966704,0.00001190072,0.001653685,0.001356021,0.0002321325,0.00002776623,0.000001916017,0.00001471226,0.00003147324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03180423,"threshold_uncertainty_score":0.6107327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03374590762390317,"score_gpt":0.3259218733195057,"score_spread":0.2921759656956026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}